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Displaying results 2201 - 2210 of 8696 in total
  1. Target

    Prostaglandin E2 receptor EP4 subtype

    go.drugbank.com/bio_entities/BE0003522
    TargetHumans

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. … May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function

    Polypeptides: Prostaglandin E2 receptor EP4 subtypeSynonyms: PGE receptor EP4 subtype, Prostanoid EP4 receptor
  2. Target

    TGF-beta receptor type-1

    go.drugbank.com/bio_entities/BE0003782
    TargetHumans

    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. … Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4.

    Polypeptides: TGF-beta receptor type-1Synonyms: TGF-beta receptor type I, TGF-beta type I receptor
  3. Target

    Ephrin type-B receptor 2

    go.drugbank.com/bio_entities/BE0004549
    TargetHumans

    May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874) … Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

    Polypeptides: Ephrin type-B receptor 2Synonyms: Tyrosine-protein kinase receptor EPH-3
  4. Target

    Discoidin domain-containing receptor 2

    go.drugbank.com/bio_entities/BE0004741
    TargetHumans

    It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. … Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2.

    Polypeptides: Discoidin domain-containing receptor 2Synonyms: Discoidin domain receptor 2, Receptor protein-tyrosine kinase TKT
  5. Target

    Glycine receptor (alpha-1/beta)

    go.drugbank.com/bio_entities/BE0004857
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...

    Polypeptides: Glycine receptor subunit beta, Glycine receptor subunit alpha-1Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor 58 kDa subunit
  6. Target

    Sphingosine 1-phosphate receptor 1

    go.drugbank.com/bio_entities/BE0008652
    TargetHumans

    Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. … G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins.

    Polypeptides: Sphingosine 1-phosphate receptor 1Synonyms: S1P receptor 1, S1P receptor Edg-1
  7. Target

    G protein-coupled receptor 12

    go.drugbank.com/bio_entities/BE0009153
    TargetHumans

    Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (PubMed:12220620) … Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162).

    Polypeptides: G protein-coupled receptor 12Function: G protein-coupled receptor activity
  8. Target

    Tyrosine-protein kinase receptor TYRO3

    go.drugbank.com/bio_entities/BE0009404
    TargetHumans

    Regulates many physiological processes including cell survival, migration and differentiation. … Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6.

    Polypeptides: Tyrosine-protein kinase receptor TYRO3
  9. Target

    Ephrin type-A receptor 1

    go.drugbank.com/bio_entities/BE0009436
    TargetHumans

    May play a role in apoptosis … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-A receptor 1Synonyms: Tyrosine-protein kinase receptor EPH, Erythropoietin-producing hepatoma receptor
  10. Target

    Ephrin type-A receptor 8

    go.drugbank.com/bio_entities/BE0009440
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Polypeptides: Ephrin type-A receptor 8Synonyms: Tyrosine-protein kinase receptor EEK