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Displaying results 2481 - 2490 of 10000 in total
  1. Pathway

    Noncanonical Wnt/Ca2+ signaling

    smpdb.ca/view/SMP0468891
    Signaling

    DAG and calcium activate protein kinase C (PKC), which in turn activates cell-division cycle 43 (Cdc42). … Increased concentrations of calcium in the cytosol also stimulate calcineurin and CAMKII. Calcineurin activates NFAT, which leads to gene transcription.

    Drugs: Calcium · Magnesium cation
    Enzymes: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  2. Drug

    Janssen COVID-19 Vaccine

    go.drugbank.com/drugs/DB15857
    ApprovedInvestigational

    The Janssen COVID-19 vaccine is available under an Emergency Use Authorization (EUA) in the US.[L41745] … Follow-up preclinical studies in rhesus monkeys[A220058] showed that the Ad26 vaccine produced a robust response and provided near perfect protection in nasal swabs and bronchoalveolar lavage following

  3. Drug

    Depemokimab

    go.drugbank.com/drugs/DB18846
    ApprovedInvestigational

    [A275338] Approved by the FDA on December 16, 2025, depemokimab is indicated as an add-on maintenance treatment for severe asthma characterized by an eosinophilic phenotype in adult and paediatric patients … [A275338, L54758] Its long duration of action is granted by seven amino acid substitutions in the heavy chain sequence.

    Categories: Amino Acids, Peptides, and Proteins
  4. Target

    Inactive phospholipase C-like protein 1

    go.drugbank.com/bio_entities/BE0001081
    TargetHumans

    Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. … Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity).

    Synonyms: Phospholipase C-deleted in lung carcinoma, Phospholipase C-related but catalytically inactive protein
  5. Indication

    B. Burgdorferi Infection

    go.drugbank.com/conditions/DBCOND0157594
    Drugs: Cefixime · Cefuroxime · Clarithromycin
    Synonyms: Arthritis in Lyme disease
  6. Indication

    Recurrent Miscarriages

    go.drugbank.com/conditions/DBCOND0032265
    Drugs: Dydrogesterone
    Synonyms: Investigation or care in a nonpregnant woman with history of recurrent pregnancy loss
  7. Indication

    Urinary Bladder Calculi

    go.drugbank.com/conditions/DBCOND0001414
    Drugs: Gluconolactone · Magnesium carbonate · beta-Pinene
    Synonyms: Calculus in bladder
  8. Drug

    Daridorexant

    go.drugbank.com/drugs/DB15031
    ApprovedInvestigational

    [A244280] Daridorexant was approved by the European Commission on May 3, 2022, as the first dual orexin receptor antagonist approved in the market,[L41725] and by Health Canada on April 26, 2023. … Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning.

    Categories: Hypnotics and Sedatives
  9. Drug

    Sepiapterin

    go.drugbank.com/drugs/DB16326
    ApprovedInvestigational

    [L53548,L53593] Sepiapterin was granted marketing authorization by the European Commission in June 2025 and by the US FDA in July 2025 for the treatment of adults and children with phenylketonuria. … It is a natural precursor of the enzymatic co-factor tetrahydrobiopterin (BH4), which activates PAH and helps reduce blood phenylalanine levels by enhancing the conformational stability of misfolded PAH

  10. Drug

    Prothrombin

    go.drugbank.com/drugs/DB11311
    ApprovedInvestigational

    Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with

    Mixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, Octaplex Powder and Solvent for Solution for InfusionCategories: Enzymes and Coenzymes, Amino Acids, Peptides, and Proteins