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Dofetilide Action Pathway
smpdb.ca/view/SMP0126189Drug actionDofetilide, brand name tikosyn, is a class III antiarrhythmic agent. This drug is used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Dofetilide increases the monophasic a...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Ajmaline Action Pathway
smpdb.ca/view/SMP0126271Drug actionAjmaline is an antiarrhythmic used to manage a variety of forms of tachycardias. It can be found under the brand names Gilurytmal, Ritmos, and Aritmina. An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Propafenone Action Pathway
smpdb.ca/view/SMP0126275Drug actionPropafenone is a Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. It can be found under the brand name Rhythmol. Used to prolong the time to recurrence of paroxys...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Quinidine Action Pathway (New)
smpdb.ca/view/SMP0126282Drug actionQuinidine is a medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. It can be found under the brand name Nuedexta. Quinidine is a D-isomer of quinine present in the bar...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Lovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigational[A181397, A181403] While all statin medications are considered equally effective from a clinical standpoint, [rosuvastatin] is considered the most potent; doses of 10 to 40mg [rosuvastatin] per day … Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsSynonyms: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate, 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactonePiroxicam Action Pathway
smpdb.ca/view/SMP0000077Drug actionPiroxicam (also named Feldene or Piroxicamum) is a nonsteroidal anti-inflammatory drug. Piroxicam can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 cat...
Enzymes: Prostaglandin E synthaseEtodolac Action Pathway
smpdb.ca/view/SMP0000084Drug actionEtodolac is a non-steroidal anti-inflammatory drug (NSAID) that can be used to treat rheumatoid arthritis and osteoarthritis. Most NSAIDs are non-selective prostaglandin G/H synthase (a.k.a. cyclooxygenase or COX) inhibitors that act on ...
Enzymes: Prostaglandin E synthaseRofecoxib Action Pathway
smpdb.ca/view/SMP0000087Drug actionRofecoxib, a non-steroidal anti-inflammatory drug (NSAID), is a highly selective inhibitor of cyclooxygenase-2 (COX-2), also known as prostaglandin G/H synthase 2. Like other NSAIDs, rofecoxib exerts its effects by inhibiting the synthes...
Enzymes: Prostaglandin E synthaseDiclofenac Action Pathway
smpdb.ca/view/SMP0000093Drug actionDiclofenac (also named Voltaren) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat prostaglandin G/H synthase related fever, swelling, pain and inflammation. Diclofenac can block prostaglandin synthesis by the act...
Enzymes: Prostaglandin E synthaseKetorolac Action Pathway
smpdb.ca/view/SMP0000098Drug actionKetorolac (also named Toradol) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to relieve pain (analgesic), reduce fever (antipyretic) and swelling. Ketorolac can block prostaglandin synthesis by the action of inhibition...
Enzymes: Prostaglandin E synthase