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Tropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnAs a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting … Tropisetron is an indole derivative with antiemetic activity.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: NAVOBAN 5 MG 1 AMPUL, Navoban 5 mg - KapselnClobetasone
go.drugbank.com/drugs/DB13158ApprovedClobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions … Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
Categories: Corticosteroids, Moderately Potent (Group II), Cytochrome P-450 SubstratesProducts: AMISOL CREAM 0.05% w/w, CLOBUTRATE CREAM 0.05% W/WCarbopol 974P
go.drugbank.com/drugs/DB05384ApprovedWithdrawnThe compound, known as BufferGel, was in advanced clinical trials for its ability to prevent pregnancy, but was discontinued. … Carbopol 974P is a highly carboxylated polymer composed of lightly cross-linked polyacrylic acid with a broad-spectrum mechanism based on acidification of pathogens.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Carbomer 974 (P), Carbomer homopolymer type BMercaptopurine Action Pathway (New)
smpdb.ca/view/SMP0126475Drug actionMercaptopurine is an antimetabolic antineoplastic agent used in the treatment and maintenance therapy of acute lymphatic leukemia (ALL), acute promyelocytic leukemia, autoimmune hepatitis, Crohn's disease … This drug is a purine analogue, so it acts by interfering with the nucleic acid biosynthesis in cells. More specifically, this molecule is an analogue of the adenine and hypoxanthine bases.
Drugs: Tetrahydrofolic acid · Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +12 moreAtomoxetine
go.drugbank.com/drugs/DB00289ApprovedInvestigationalLong-acting formulations of psychostimulants (such as [DB00422], [DB01576], and [DB01255]) are typically considered the most effective and first-line treatment for ADHD in adults and children as recommended … [A18262] This is beneficial in the treatment of ADHD as DA activation in the subcortical NA and striatum is associated with many stimulant-associated side effects and an increase in abuse potential, which
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: STRATTERA® 80 MG, ATTENTHO®25 MG CAPSULASInfluenza A virus A/Guangdong-Maonan/SWL1536/2019 CNIC-1909 (H1N1) antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB15703ApprovedInvestigationalInactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. … In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques.
Mixtures: Fluarix Tetra Injektionssuspension in einer Fertigspritze, VaxigripTetra Injektionssuspension in einer FertigspritzeSynonyms: Influenza A virus A/Guangdong-Maonan/SWL1536/2019 CNIC-1909 (H1N1) antigen (formaldehyde inactivated)Yohimbine
go.drugbank.com/drugs/DB01392ApprovedInvestigationalVet approvedWithdrawnA plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Categories: Drugs Used in Erectile Dysfunction, Dopamine D2 Receptor AntagonistsInternational brands: Baron-XAmphetamine
go.drugbank.com/drugs/DB00182ApprovedIllicitInvestigational[L5194] During World War II, amphetamine was used to promote wakefulness in the soldiers. … After being proven to reduce drug-induced anesthesia and produce arousal and insomnia, amphetamine racemic mix was registered by Smith, Kline and French in 1935.
Mixtures: Mixed Salts of a Single-Entity Amphetamine Product, Mixed Salts of a Single-Entity Amphetamine ProductCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesCorynebacterium diphtheriae
go.drugbank.com/drugs/DB09877ApprovedInvestigationalThe bacteria culture is grown in a medium and through purification, diphtheria toxin is detoxified with formaldehyde and diafiltered. … The vaccine is intramuscularly administered to provide active immunization against diphtheria in infants and children.
Mixtures: Boostrix Injektionssuspension in einer Fertigspritze, Boostrix Polio - Injektionssuspension in einer FertigspritzeBopindolol
go.drugbank.com/drugs/DB08807ExperimentalBopindolol (INN) is an ester prodrug for the beta blocker [pindolol].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates