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Displaying results 281 - 290 of 2828 in total
  1. Drug

    Quinethazone

    go.drugbank.com/drugs/DB01325
    Approved

    Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.

    Categories: Membrane Transport Modulators, Genito Urinary System and Sex Hormones
  2. Target

    Synaptic vesicular amine transporter

    go.drugbank.com/bio_entities/BE0000118
    TargetTransporterHumans

    Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). … Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:23363473, PubMed:37914936, PubMed:38081299, PubMed:38517752,

    Polypeptides: Synaptic vesicular amine transporterSynonyms: Vesicular amine transporter 2, Vesicular monoamine transporter 2
  3. Target

    Mitochondrial ornithine transporter 2

    go.drugbank.com/bio_entities/BE0000258
    TargetHumans

    Mitochondrial transporter of the positively charged amino acids ornithine, lysine and arginine, and the neutral amino acid citrulline (PubMed:12807890). … In addition, transports the basic amino acids histidine, homoarginine, and asymmetric dimethylarginine (aDMA), but not symmetric DMA, and the D-forms of lysine, arginine, ornithine and histidine (PubMed

    Polypeptides: Mitochondrial ornithine transporter 2Function: L-arginine transmembrane transporter activity
  4. Target

    Sodium-dependent proline transporter

    go.drugbank.com/bio_entities/BE0000723
    TargetHumans

    Brain specific sodium (and chloride)-dependent proline transporter (PubMed:7651355).

    Polypeptides: Sodium-dependent proline transporterFunction: L-proline transmembrane transporter activity
  5. Target

    Equilibrative nucleoside transporter 1

    go.drugbank.com/bio_entities/BE0001204
    TargetTransporterEnzymeCarrierHumans

    Functions as a Na(+)-independent transporter (PubMed:8986748). … Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448).

    Polypeptides: Equilibrative nucleoside transporter 1Synonyms: es nucleoside transporter, Nucleoside transporter, es-type
  6. Target

    Organic anion transporter 3

    go.drugbank.com/bio_entities/BE0003645
    TargetTransporterEnzymeHumans

    E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (PubMed:26377792). … Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:22108572, PubMed:23832370).

    Polypeptides: Organic anion transporter 3Function: prostaglandin transmembrane transporter activity
  7. Target

    Equilibrative nucleoside transporter 4

    go.drugbank.com/bio_entities/BE0004775
    TransporterTargetHumans

    Also transports guanidine (PubMed:16099839) … Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed

    Polypeptides: Equilibrative nucleoside transporter 4Synonyms: Plasma membrane monoamine transporter
  8. Target

    Equilibrative nucleoside transporter 3

    go.drugbank.com/bio_entities/BE0010035
    TransporterHumans

    Protons are not cotransported but likely modulate transport by altering the ionization state of the transporter which dictates its conformation, thereby regulating substrate permeability (PubMed:28729424 … Regulates inflammasome activation via dual roles in urate and adenosine transport (PubMed:41476938)

    Polypeptides: Equilibrative nucleoside transporter 3Function: cytidine transmembrane transporter activity
  9. Target

    Lysosomal cobalamin transporter ABCD4

    go.drugbank.com/bio_entities/BE0011060
    TransporterHumans

    Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791) … Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:28572511, PubMed:31467407, PubMed:33845046

    Polypeptides: Lysosomal cobalamin transporter ABCD4Function: ABC-type vitamin B12 transporter activity
  10. Target

    Organic anion transporter 7

    go.drugbank.com/bio_entities/BE0016822
    TransporterHumans

    Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised (PubMed:26239079). … Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS

    Polypeptides: Organic anion transporter 7Function: secondary active transmembrane transporter activity