Synaptic vesicular amine transporter

BE0000118ProteinHumansSLC18A2

Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. It is acted on by 32 drugs in DrugBank.

Gene name
SLC18A2
UniProtKB entry
Q05940Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Residues / weight
514 residues · 55,712 Da
Also known as
Solute carrier family 18 member 2 · SVMT · VAT2 · Vesicular amine transporter 2 · Vesicular monoamine transporter 2

Resolves to

Protein
UniProtQ05940UniProt nameVMAT2_HUMAN
Gene
HGNCHGNC:10935NCBI Gene6571GenBank292335GeneCardsSLC18A2
Pharmacology
IUPHAR/GtoPdb1012KEGGhsa:6571
Structure
PDB8JSWPDB8JSXPDB8JT5
Drugs

What you can answer from here — as of September 07, 2019

32DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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104+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Synaptic vesicular amine transporter, how selective are they, and which programs against it are still in active trials?

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