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Cysteine and glycine-rich protein 1
go.drugbank.com/bio_entities/BE0009098TargetHumansCould play a role in neuronal development
Polypeptides: Cysteine and glycine-rich protein 1TRAF2 and NCK-interacting protein kinase
go.drugbank.com/bio_entities/BE0009399TargetHumansSerine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. … Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
Polypeptides: TRAF2 and NCK-interacting protein kinaseSignal transducer and activator of transcription 5B
go.drugbank.com/bio_entities/BE0000891TargetHumansSignal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Polypeptides: Signal transducer and activator of transcription 5BSignal transducer and activator of transcription 3
go.drugbank.com/bio_entities/BE0003462TargetHumansMay mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). … Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:11294841, PubMed:12359225, PubMed:12873986
Polypeptides: Signal transducer and activator of transcription 3Disintegrin and metalloproteinase domain-containing protein 10
go.drugbank.com/bio_entities/BE0002404TargetHumansResponsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase … Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10Disintegrin and metalloproteinase domain-containing protein 28
go.drugbank.com/bio_entities/BE0003872TargetHumansMay play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IICalcium and integrin-binding family member 2
go.drugbank.com/bio_entities/BE0008698TargetHumansRequired for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). … Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair
Polypeptides: Calcium and integrin-binding family member 2Troponin C, slow skeletal and cardiac muscles
go.drugbank.com/bio_entities/BE0001024TargetHumansTn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.
Polypeptides: Troponin C, slow skeletal and cardiac musclesDisintegrin and metalloproteinase domain-containing protein 17
go.drugbank.com/bio_entities/BE0003754TargetHumansActs as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769, PubMed:38771644 … Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansRecognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation … Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and II