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Metiamide Action Pathway
smpdb.ca/view/SMP0000735Drug actionMetiamide is a histamine H2-receptor antagonist that can bind and inhibit histamine H2-receptor to prevent the histamine effects on basolateral memrbane in gastric parietal cell. Binding and inhibition of histamine H2-receptor can lead t...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Ethacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionEthacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Kidney Function - Distal Convoluted Tubule
smpdb.ca/view/SMP0121012PhysiologicalIn addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers. … As a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure.
Enzymes: Chloride channel protein ClC-Ka, Potassium-transporting ATPase alpha chain 1Kidney Function - Ascending Limb of The Loop of Henle
smpdb.ca/view/SMP0121010PhysiologicalChloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … In addition, the three ions are transported across the basolateral membrane (closest to the renal interstitium) via other means such as the sodium potassium ATPase transports and the chloride channels
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Triamterene Action Pathway (New)
smpdb.ca/view/SMP0126281Drug actionTriamterene maintains or increases sodium excretion, thereby increasing the excretion of water, and reducing the excess loss of potassium, hydrogen, and chloride ions by inhibiting the distal tubular exchange … This reduces the driving force for potassium movement into the tubular lumen and thus decreases potassium excretion.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Quinethazone Action Pathway
smpdb.ca/view/SMP0123030Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Indapamide Diuretic Action Pathway
smpdb.ca/view/SMP0123031Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Furosemide Diuretic Action Pathway
smpdb.ca/view/SMP0122712Drug actionFurosemide may also inhibit sodium and chloride reabsorption in the proximal and distal tubules.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Torasemide Action Pathway (New)
smpdb.ca/view/SMP0124537Drug actionTorasemide is a loop diuretic drug, administered orally or intravenously to treat hypertension and edema associated with heart failure, renal failure, or liver disease. It targets the nephrons of the kidney, mainly the ascending limb of ...
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Hydrochlorothiazide Diuretic Action Pathway
smpdb.ca/view/SMP0122688Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1