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Displaying results 291 - 300 of 10000 in total
  1. Pathway

    Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

    smpdb.ca/view/SMP0000320
    Signaling

    The A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. … The A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension.

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Adenosine receptor A2a
  2. Pathway

    Intracellular Signalling Through Histamine H2 Receptor and Histamine

    smpdb.ca/view/SMP0000335
    Signaling

    The H2 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Histamine H2 receptor
  3. Pathway

    Fc Epsilon Receptor I Signaling in Mast Cells

    smpdb.ca/view/SMP0000358
    Signaling

    Fc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.

    Drugs: Heparin · Calcium · Magnesium cation · Zinc · Prostaglandin D2 · Arachidonic Acid
    Enzymes: Growth factor receptor-bound protein 2, High affinity immunoglobulin epsilon receptor subunit alpha
  4. Pathway

    Activation of PKC Through G Protein-Coupled Receptor

    smpdb.ca/view/SMP0000749
    Signaling

    IP3 can bind Ins3P receptor to open calcium channel by diffusion from cytoplasm to ER. Activated calcium channel will release the calcium from ER into cytoplasm.

    Drugs: Calcium
    Enzymes: Inositol 1,4,5-trisphosphate receptor type 1
  5. Pathway

    Intracellular Signalling Through PGD2 receptor and Prostaglandin D2

    smpdb.ca/view/SMP0000343
    Signaling

    The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream

    Drugs: ATP · Magnesium cation · Prostaglandin D2 · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Prostaglandin D2 receptor
  6. Drug

    Obecabtagene autoleucel

    go.drugbank.com/drugs/DB17362
    ApprovedInvestigational

    Obecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [A265050] On November 8, 2024, obecabtagene autoleucel was approved by the FDA for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia.

    Categories: Genetically-modified Autologous T Cells, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, SELF-INACTIVATING LENTIVIRAL VECTOR CONSISTING OF 5' FUSION BETWEEN THE CMV PROMOTER AND HIV LTR, WHERE THE CMV PROMOTER REPLACES THE U3 REGION.
  7. Indication

    Herpes Zoster

    go.drugbank.com/conditions/DBCOND0028191
    Drugs: Acyclovir · Brivudine · Econazole · Famciclovir · Lysozyme · Ox bile extract +3 more
    Synonyms: Zoster [herpes zoster], Zoster
  8. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor while (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits … These pathways are complementary and synergistic, improving tramadol's ability to modulate the perception of and response to pain.

    Mixtures: STADIUM-T, TRALIC TPCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, NMDA Receptor Antagonists
  9. Drug

    Inolimomab

    go.drugbank.com/drugs/DB15628
    Investigational

    Inolimomab is under investigation as an agent to treat steroid-resistant graft vs host disease. … It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry a higher risk of infections.[A241385]

    Synonyms: Immunoglobulin G1, anti-(human interleukin 2 receptor alpha-chain) (mouse monoclonal B-B10 gammal-chain), disulfide with mouse monoclonal B-B10 kappa-chain, dimer
  10. Drug

    Mapatumumab

    go.drugbank.com/drugs/DB18945
    Investigational

    Mapatumumab is under investigation in clinical trial NCT00094848 (Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-hodgkin's Lymphoma (NHL)).

    Synonyms: Immunoglobulin g1, anti-(human cytokine receptor dr4 (death receptor 4)) (human monoclonal trm-1 heavy chain), disulfide with human monoclonal trm-1 .lambda.-chain, dimer, Immunoglobulin g1, anti-(human cytokine receptor dr4 (death receceptor 4)) (human monoclonal trm-1 heavy chain), disulfide with human monoclonal trm-1 .lambda.-chain, dimer