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Potassium voltage-gated channel subfamily A member 5
go.drugbank.com/bio_entities/BE0004717TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. Th...
Polypeptides: Potassium voltage-gated channel subfamily A member 5ATP-binding cassette sub-family G member 5
go.drugbank.com/bio_entities/BE0004750TransporterHumansABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356).
Polypeptides: ATP-binding cassette sub-family G member 5Dual specificity mitogen-activated protein kinase kinase 5
go.drugbank.com/bio_entities/BE0009460TargetHumansActs as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac d...
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 5Synonyms: MEK 5, MAPKK 55'-AMP-activated protein kinase subunit gamma-1
go.drugbank.com/bio_entities/BE0009988TargetHumansAMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ...
Polypeptides: 5'-AMP-activated protein kinase subunit gamma-1Citalopram
go.drugbank.com/drugs/DB00215ApprovedInvestigationalIt is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs. … [A261316,A14720] Specifically, it has a very minimal effect on dopamine and norepinephrine transportation and virtually no affinity for muscarinic, histaminergic, or GABAergic receptors.
Categories: Serotonin 5-HT2 Receptor Antagonists, P-glycoprotein inhibitorsProducts: CITALOPRAM EG, CITALOPRAM EG STADAUmeclidinium
go.drugbank.com/drugs/DB09076ApprovedInvestigational[A7715] Maintenance of the airway is controlled by the parasympathetic nervous system, particularly by the abundance of the muscarinic subtype 3 (M3) in the airway smooth muscle. … COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less than
Synonyms: 1-[2-(benzyloxy)ethyl]-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octaneMixtures: ANORO ELLIPTA 62.5 MCG + 25 MCG KULLANIMA HAZIR INHALASYON TOZU, 3 X 30 DOZ, TRELEGY ELLIPTA INHALATION POWDER 100 MCG/62.5 MCG/25 MCG3-oxo-5-alpha-steroid 4-dehydrogenase 1
go.drugbank.com/bio_entities/BE0000539TargetEnzymeHumansCatalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Synonyms: Steroid 5-alpha-reductase 1High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
go.drugbank.com/bio_entities/BE0000706TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912)
Polypeptides: High affinity 3',5'-cyclic-AMP phosphodiesterase 7AFunction: 3',5'-cyclic-AMP phosphodiesterase activityMitogen-activated protein kinase kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0009474TargetHumansMay play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 5Synonyms: MEKKK 5, MEK kinase kinase 5Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
go.drugbank.com/bio_entities/BE0014411TargetHumansAlso has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). … Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity
Polypeptides: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRNFunction: 3'-5' DNA helicase activity