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Antihemophilic factor, human recombinant
go.drugbank.com/drugs/DB00025ApprovedInvestigationalHuman recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
Mixtures: HAEMATE P, HAEMATE PCategories: Hemophilia AAmphotericin B
go.drugbank.com/drugs/DB00681ApprovedInvestigationalranging from 0.03 to 1.0 mcg/mL in vitro. … Amphotericin B shows a high order of in vitro activity against many species of fungi.
Synonyms: AMPH-b, Amfotericina BSalts: Amphotericin B Cholesteryl Sulfate ComplexATP-binding cassette sub-family B member 5
go.drugbank.com/bio_entities/BE0002369TargetTransporterHumansEnergy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays ...
Polypeptides: ATP-binding cassette sub-family B member 5Potassium voltage-gated channel subfamily KQT member 5
go.drugbank.com/bio_entities/BE0002400TargetHumansPore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCN...
Polypeptides: Potassium voltage-gated channel subfamily KQT member 5Synonyms: KQT-like 5Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma
go.drugbank.com/bio_entities/BE0003556TargetHumansInhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade.
Polypeptides: Rod cGMP 3',5'-cyclic phosphodiesterase subunit gammaFunction: 3',5'-cyclic-nucleotide phosphodiesterase activityATP-binding cassette sub-family C member 5
go.drugbank.com/bio_entities/BE0003639TransporterTargetHumansATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid a...
Polypeptides: ATP-binding cassette sub-family C member 5Synonyms: Multidrug resistance-associated protein 5Potassium voltage-gated channel subfamily A member 5
go.drugbank.com/bio_entities/BE0004717TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. Th...
Polypeptides: Potassium voltage-gated channel subfamily A member 5ATP-binding cassette sub-family G member 5
go.drugbank.com/bio_entities/BE0004750TransporterHumansABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356).
Polypeptides: ATP-binding cassette sub-family G member 5Dual specificity mitogen-activated protein kinase kinase 5
go.drugbank.com/bio_entities/BE0009460TargetHumansActs as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac d...
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 5Synonyms: MEK 5, MAPKK 55'-AMP-activated protein kinase subunit gamma-1
go.drugbank.com/bio_entities/BE0009988TargetHumansAMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ...
Polypeptides: 5'-AMP-activated protein kinase subunit gamma-1