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Diabetic Neuropathies
go.drugbank.com/conditions/DBCOND0028190Drugs: Amitriptyline · Botulinum toxin type A · Citalopram · Cyanocobalamin · Desipramine · Lipoic acid +1 moreSynonyms: Neuropathy co-occurrent and due to diabetes mellitusVitamin B1 deficiency
go.drugbank.com/conditions/DBCOND0015755Synonyms: (Thiamine and niacin deficiency states) or (vitamin B1 deficiency)Simeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnLike all NS3/4A inhibitors, simeprevir is a serine protease inhibitor in similarity to [DB08873] and [DB05521] but is classified as a second generation protease inhibitor. … Simeprevir was approved by the FDA in November 2014 and is marketed under the brand name Olysio as oral tablets.
Categories: Genito Urinary System and Sex Hormones, Gynecological Antiinfectives and AntisepticsSilodosin
go.drugbank.com/drugs/DB06207ApprovedInvestigational[A231159] Silodosin was first approved by the FDA in October 2008 [A231159] and it is also approved in Europe and Canada. … [A231159] Silodosin works by binding to α<sub>1A</sub>-adrenoceptors with high affinity and relaxing the lower urinary tract, thereby improving urinary symptoms and alleviating bladder outlet obstruction
Categories: Genito Urinary System and Sex Hormones, Drugs Used in Benign Prostatic HypertrophyFomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnIt is an antiviral agent that was used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. … It was discovered by scientists at the National Institutes of Health (NIH) and was first developed by _Isis Pharmaceuticals_ and subsequently licensed to _Novartis_ [A31990].
Categories: Nucleic Acids, Nucleotides, and Nucleosides, Compounds used in a research, industrial, or household settingBesilesomab
go.drugbank.com/drugs/DB13979ApprovedUtilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and use in various European countries like Italy, France, Germany, Spain, Portugal, Norway, Sweden, the … Netherlands, and the United Kingdom [L1564].
Categories: Amino Acids, Peptides, and ProteinsAliskiren
go.drugbank.com/drugs/DB09026ApprovedInvestigational[A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. … Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension.
Categories: valsartan and aliskiren, aliskiren and amlodipineIL15-NK Cell
go.drugbank.com/drugs/DB15725InvestigationalIn particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to. … Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity.
Synonyms: IL15-NK CellRelugolix
go.drugbank.com/drugs/DB11853ApprovedInvestigationalIt was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids,[A225816] and more recently by the United States' FDA in 2020, under the brand name … [A225926] In May 2021, the FDA approved the combination product made up of relugolix, [estradiol], and [norethindrone] under the market name Myfembree for the first once-daily treatment for the management
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsStrontium chloride Sr-89
go.drugbank.com/drugs/DB09498ApprovedIt is usually presented mainly in patients with prostatic and breast cancer, as well as in cancer of lung, bladder and thyroid. … Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer.[A31264] Bone metastases is a common and severe complication presented in advanced stages of the disease.