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Displaying results 3321 - 3330 of 10000 in total
  1. Drug

    Grepafloxacin

    go.drugbank.com/drugs/DB00365
    ApprovedWithdrawn

    Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States … Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
  2. Indication

    Dental Caries Extending Into Dentine

    go.drugbank.com/conditions/DBCOND0061100
    Drugs: Hydrogen fluoride · Olaflur · Sodium bicarbonate · Sodium fluoride
    Synonyms: Dental caries confined to enamel and dentine
  3. Indication

    Seborrheic Dermatitis

    go.drugbank.com/conditions/DBCOND0036095
    Drugs: Coal tar · Flutrimazole · Gentamicin · Ketoconazole · Levomenthol · Miconazole +8 more
    Synonyms: Greasy skin due to excessive secretion of sebum (disorder)
  4. Indication

    Substance Addiction

    go.drugbank.com/conditions/DBCOND0033529
    Drugs: Valpromide
    Synonyms: Addiction to drugs
  5. Drug

    Ganaxolone

    go.drugbank.com/drugs/DB05087
    ApprovedInvestigational

    [A3197] Ganaxolone belongs to a class of compounds referred to as neurosteroids. … [A3197] Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABA<sub>A</sub> receptors to enhance their inhibitory effects

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Substrates
  6. Drug

    Linoleic acid

    go.drugbank.com/drugs/DB14104
    Approved

    Mixtures: SIMILAC ALIMENTUM 400 G TOZ, Gla 130 Primrose Oil
  7. Drug

    MK-0777

    go.drugbank.com/drugs/DB12238
    Investigational

    MK-0777 has been used in trials studying the treatment of Schizophrenia, Anxiety Disorder, and Generalized Anxiety Disorder.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  8. Drug

    MK-886

    go.drugbank.com/drugs/DB16739
    Experimental

    MK-886 is an experimental inhibitor of leukotriene synthesis.

  9. Drug

    MK-4965

    go.drugbank.com/drugs/DB08460
    Experimental

    MK-4965 is an HIV-1 reverse transcriptase inhibitor.

  10. Drug

    Estradiol benzoate

    go.drugbank.com/drugs/DB13953
    ApprovedVet approvedWithdrawn

    [DB00783] is commonly produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10%). … First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a chance to enter systemic circulation and exert its estrogenic effects [A12102].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 Substrates