Seborrheic Dermatitis (DBCOND0036095)

Identifiers

Synonyms

Seborrhea / Seborrhoeic dermatitis / Dermatitis, Seborrheic / Seborrheic dermatitis / Seborrheic dermatitis, unspecified / Dermatitis seborrheic / Seborrheic dermatitis (disorder) / Dermatitis seborrhoeic / Seborrheic eczema / Eczema seborrhoeic / Seborrhoea / Skin seborrhoeic / Seborrhoeic eczema / Seborrhoeic dermatitis, unspecified / Skin seborrheic

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Coal tar	Relieving itching, irritation, redness, dryness, scaling, and flaking of the skin caused by psoriasis, seborrhea, or eczema.	No drug targets
Flutrimazole	A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.	No drug targets
Gentamicin	An aminoglycoside used to treat a wide variety of aerobic infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget NH(3)-dependent NAD(+) synthetasetarget Dihydrofolate reductasetarget 23S ribosomal RNAtarget Bacterial outer membranetarget Cytoplasmic membranetarget Low-density lipoprotein receptor-related protein 2transporter Solute carrier family 22 member 2transporter ATP-binding cassette sub-family C member 2transporter
Ketoconazole	A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Lanosterol 14-alpha demethylasetarget Androgen receptortarget Steroid 17-alpha-hydroxylase/17,20 lyasetarget Steroid 21-hydroxylasetarget Voltage-gated inwardly rectifying potassium channel KCNH2target Nuclear receptor subfamily 1 group I member 2target Nuclear receptor subfamily 1 group I member 3target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 4F12enzyme Cytochrome P450 4F2enzyme Albumincarrier Sex hormone-binding globulincarrier Aromataseenzyme UDP-glucuronosyltransferase 1A7enzyme Lanosterol 14-alpha demethylasetarget
Levomenthol	An organic compound used to treat mild to moderate muscle and joint pain.	Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target Transient receptor potential cation channel subfamily V member 3target Kappa-type opioid receptortarget Voltage-dependent L-type calcium channeltarget Cytochrome P450 3A4enzyme
Miconazole	An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.	Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Nitric oxide synthase 3target Nitric oxide synthase, inducibletarget Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Nuclear receptor subfamily 1 group I member 2target Lanosterol 14-alpha demethylaseenzyme Aromataseenzyme Calcium-activated potassium channeltarget Voltage-gated Potassium Channelstarget Inward rectifier potassium channeltarget Voltage gated L-type calcium channeltarget Albumincarrier Cytochrome P450 2C8enzyme
Pine tar	A medication indicated in itchy, inflamed, and flaky skin conditions.	No drug targets
Potassium carbonate	Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent...	No drug targets
Pyrithione	An antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis.	Potassium voltage-gated channel subfamily KQT member 1target
Roflumilast	A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat skin conditions such as plaque psoriasis and atopic dermatitis.	Cytochrome P450 3A4enzyme cAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)target Cytochrome P450 1A2enzyme
Salicylic acid	An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.	Albumincarrier Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Carbonic anhydrase 6target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 4target Carbonic anhydrase 1target
Selenium Sulfide	An antifungal used to treat dandruff, seborrheic dermatitis of the scalp, and tinea capitis.	No drug targets
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier
Urea	A keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.	Arginase-1target Carbonic anhydrase 2target Catenin beta-1target Sulfoxide reductase catalytic subunit YedYtarget Urea transporter 2transporter Urea transporter 1transporter Dihydrofolate reductasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01139749	Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea	Ciclopirox Isotretinoin Pyrithione Salicylic acid	treatment	4	unknown_status
NCT01254162	Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers	No drug interventions	treatment	2	completed
NCT02494297	DUS on the Prescribing Indications for CPA/EE in 5 European Countries	No drug interventions	Not Available	Not Available	completed
NCT00565279	Efficacy and Safety of ASF1057 in the Treatment of Seborrhoeic Dermatitis	No drug interventions	treatment	3	completed
NCT04445987	Long-Term Safety of ARQ-154 Foam in Subjects With Seborrheic Dermatitis	No drug interventions	treatment	2	completed
NCT01315951	Petrolatum's Effect on Initial Symptoms of Nonscalp Seborrheic Dermatitis and Preventing Exacerbation	Benzalkonium Petrolatum	treatment	Not Available	terminated
NCT03807453	Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients	No drug interventions	Not Available	Not Available	completed
NCT00991198	The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage	No drug interventions	treatment	2	completed
NCT04973228	Trial of PDE4 Inhibition With Roflumilast (ARQ-154) Foam 0.3% for the Management of Seborrheic Dermatitis (STRATUM)	Roflumilast	treatment	3	completed
NCT01703793	Safety and Efficacy Study in Subjects With Seborrheic Dermatitis	No drug interventions	treatment	2	completed
NCT03688971	Omiganan Twice a Day (BID) in Patients With Facial Seborrheic Dermatitis	Ketoconazole Omiganan	treatment	2	unknown_status
NCT00403559	A 4 Week Study of Elidel (Pimecrolimus) for the Treatment of Seborrheic Dermatitis	Ketoconazole Pimecrolimus	treatment	2	completed
NCT01591070	Proactive Treatment of Tacrolimus Ointment for Adult Facial Seborrheic Dermatitis	Tacrolimus	treatment	4	completed
NCT05942248	The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic Dermatitis	No drug interventions	other	Not Available	recruiting
NCT01024374	Evaluation of the Effectiveness of a Product Containing Topical Hydrocortisone in the Treatment of Seborrheic Dermatitis of the Face	No drug interventions	Not Available	Not Available	unknown_status
NCT05787860	Ruxolitinib in Seborrheic Dermatitis	Ruxolitinib	treatment	2	completed
NCT04091646	Safety and Efficacy of ARQ-154 Foam in Subjects With Seborrheic Dermatitis	Roflumilast	treatment	2	completed
NCT02349854	Neurobiology of the Scalp in Seborrheic Dermatitis	No drug interventions	Not Available	Not Available	completed
NCT02749383	A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Seborrheic Dermatitis	PAC-14028	treatment	2	completed
NCT03114111	Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis	Aminolevulinic acid	treatment	0	completed
NCT06013371	PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea	PF-07038124	treatment	2	recruiting
NCT05105139	Study to Evaluate the Safety of Sebryl® and Sebryl Plus® in Seborrheic Dermatitis and Psoriasis of Scalp	No drug interventions	Not Available	Not Available	completed
NCT03567980	A Proof of Concept Clinical Trial Evaluating the Safety and Efficacy of Eucrisa (Crisaborole) in Patients With Seborrheic Dermatitis	Crisaborole	treatment	4	completed
NCT01203189	Seborrheic Dermatitis: Ketoconazole 2% Foam Versus Ketoconazole 2% Shampoo	Ketoconazole	treatment	Not Available	completed
NCT05319444	Cleansing Device for the Treatment of Scalp and Hair Conditions	No drug interventions	treatment	Not Available	recruiting
NCT02656368	Safety and Efficacy of SEBORRHEAMEDIS Face Cream in Patients With Seborrheic Dermatitis	No drug interventions	treatment	Not Available	completed
NCT04472546	Use of the SpiderMass for in Vivo Analysis of the Skin in Five Chronic Inflammatory Dermatosis	No drug interventions	basic_science	Not Available	completed
NCT00767546	Botulinum Toxin for Treatment of Seborrhic Dermatitis in Parkinsonian Patients	No drug interventions	treatment	1	unknown_status
NCT00830908	HairMax LaserComb Open Label Study to Treat Seborrheic Dermatitis	No drug interventions	treatment	Not Available	completed
NCT01011621	Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis	Betamethasone Prednisolone acetate	treatment	3	unknown_status
NCT06578962	Efficacy of a Cosmetic Shampoo RV3438G in Reccurent Squamous States	No drug interventions	Not Available	Not Available	completed
NCT03830177	Safety and Efficacy of a Topical Scalp Treatment for Dry Scalp Conditions in Children and Adult	No drug interventions	treatment	1 / 2	unknown_status
NCT05225493	HIV Indicator Diseases in Hospital and Primary Care	No drug interventions	Not Available	Not Available	unknown_status
NCT00703846	STUDY TO ASSESS THE LONG-TERM SAFETY OF EXTINA (KETOCONAZOLE) FOAM, 2%	Ketoconazole	treatment	4	completed