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Displaying results 3661 - 3670 of 10000 in total

Drug
Pizotifen
go.drugbank.com/drugs/DB06153
Approved
[A32532] It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. … Sandomigran is available in a number of countries but is not approved by the FDA nor EMA.
Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-1 Receptor AntagonistsProducts: SANDOMIGRAN 0,5 MG KAPLI TABLET, 30 ADET, Pizogran Tablet 0.5 mg
Drug
Flunitrazepam
go.drugbank.com/drugs/DB01544
ApprovedIllicit
Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. … Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: Rohypnol 1 mg - Filmtabletten, ROHYPNOL ROCHE TABLETAS 1 MG
Target
Deoxycytidylate 5-hydroxymethyltransferase
go.drugbank.com/bio_entities/BE0003183
TargetEnterobacteria phage T4
Polypeptides: Deoxycytidylate 5-hydroxymethyltransferaseFunction: deoxycytidylate 5-hydroxymethyltransferase activity
Target
Histone deacetylase 5
go.drugbank.com/bio_entities/BE0009578
TargetHumans
In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional reg...
Polypeptides: Histone deacetylase 5
Target
Melanocortin receptor 5
go.drugbank.com/bio_entities/BE0009684
TargetHumans
G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8396929). Upon activation, couples to G(s) prot...
Polypeptides: Melanocortin receptor 5
Target
Pepsin A-5
go.drugbank.com/bio_entities/BE0009737
TargetHumans
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent
Polypeptides: Pepsin A-5Synonyms: Pepsinogen-5
Target
Integrin beta-5
go.drugbank.com/bio_entities/BE0012746
TargetHumans
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand
Polypeptides: Integrin beta-5
Drug
Spectinomycin
go.drugbank.com/drugs/DB00919
ApprovedVet approvedWithdrawn
It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingProducts: TROBICIN FOR INJECTION 2 g/vial, Spectro 5% w/v Oral Solution
Drug
Zotepine
go.drugbank.com/drugs/DB09225
ApprovedWithdrawn
Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA.
Categories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2A Receptor AntagonistsProducts: ZOLEPTIL © 50 MG TABLETAS RECUBIERTAS.
Drug
Delamanid
go.drugbank.com/drugs/DB11637
ApprovedInvestigational
Multidrug-resistant tuberculosis may also require more than 2 years of chemotherapy and second-line therapies with narrow therapeutic index [A31968]. … It is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in a combination regimen.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: (2R)-2-methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo(2,1-B)(1,3)oxazole, Imidazo(2,1-B)oxazole, 2,3-dihydro-2-methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)-1-piperidinyl)phenoxy)methyl)-, (2R)-