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Displaying results 3731 - 3740 of 10000 in total
  1. Drug

    Calcium ascorbate

    go.drugbank.com/drugs/DB14483
    ApprovedNutraceutical

    Mixtures: Ester-C 500 mg, Ester-C 500 mgCategories: Vitamin C and analogues, Diet, Food, and Nutrition
  2. Drug

    Luspatercept

    go.drugbank.com/drugs/DB12281
    ApprovedInvestigational

    Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1. … [L42455] Luspatercept is novel in that it ameliorates anemia via action on late-stage erythropoiesis, in contrast to typical erythropoiesis-stimulating agents (ESAs), such as [darbepoetin alfa] and [epoetin

    Categories: Enzymes and Coenzymes, Blood and Blood Forming OrgansProducts: Reblozyl 25 mg powder for solution for injection, Reblozyl 75 mg powder for solution for injection
  3. Drug

    Raltitrexed

    go.drugbank.com/drugs/DB00293
    ApprovedInvestigational

    Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

    Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsProducts: TOMUDEX 2 MG FLAKON, 1 ADET, TOMUDEX ® 2 MG
  4. Drug

    Midostaurin

    go.drugbank.com/drugs/DB06595
    ApprovedInvestigational

    It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108]. … Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3.

    Categories: Antineoplastic and Immunomodulating Agents, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 4'-N-benzoylstaurosporine
  5. Target

    Sodium channel protein type 5 subunit alpha

    go.drugbank.com/bio_entities/BE0000197
    TargetHumans

    Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). Navs, also called VGSCs (voltage-gated sod...

    Polypeptides: Sodium channel protein type 5 subunit alpha
  6. Target

    Tumor necrosis factor receptor superfamily member 5

    go.drugbank.com/bio_entities/BE0001196
    TargetHumans

    Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

    Polypeptides: Tumor necrosis factor receptor superfamily member 5
  7. Target

    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

    go.drugbank.com/bio_entities/BE0001223
    TargetHumans

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibitin...

    Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3BFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  8. Target

    Intracellular exo-alpha-(1->5)-L-arabinofuranosidase

    go.drugbank.com/bio_entities/BE0001766
    TargetGeobacillus stearothermophilus

    Catalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in different hemicellulosic homopolysaccharides (branched and debranched arabinans).

    Polypeptides: Intracellular exo-alpha-(1->5)-L-arabinofuranosidaseSynonyms: Intracellular arabinan exo-alpha-(1->5)-L-arabinosidase
  9. Target

    NAD-dependent protein deacylase sirtuin-5, mitochondrial

    go.drugbank.com/bio_entities/BE0003362
    TargetHumans

    NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 an...

    Polypeptides: NAD-dependent protein deacylase sirtuin-5, mitochondrialSynonyms: SIR2-like protein 5, Regulatory protein SIR2 homolog 5
  10. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase

    go.drugbank.com/bio_entities/BE0004887
    EnzymeTargetHumans

    Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069) … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: 5 alpha-SR2, Steroid 5-alpha-reductase 1