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Displaying results 381 - 390 of 1809 in total
  1. Target

    Dopamine receptor D4

    go.drugbank.com/bio_entities/BE0000389
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:16423344

    Polypeptides: Dopamine receptor D4Synonyms: Dopamine D4 receptor, D(2C) dopamine receptor
  2. Target

    Endothelin-1 receptor

    go.drugbank.com/bio_entities/BE0000521
    TargetHumans

    Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Endothelin-1 receptorSynonyms: Endothelin receptor type A
  3. Target

    Folate receptor gamma

    go.drugbank.com/bio_entities/BE0000652
    TargetHumans

    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate

    Polypeptides: Folate receptor gammaSynonyms: Folate receptor 3
  4. Target

    Dopamine receptor D2

    go.drugbank.com/bio_entities/BE0000756
    TargetHumans

    Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). … Also acts as a receptor for D-lysergic (LSD) psychedelic drug (PubMed:40683247)

    Polypeptides: Dopamine receptor D2Synonyms: Dopamine D2 receptor
  5. Target

    Glutamate receptor 4

    go.drugbank.com/bio_entities/BE0000830
    TargetHumans

    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). … Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic

    Polypeptides: Glutamate receptor 4Synonyms: AMPA-selective glutamate receptor 4, Glutamate receptor ionotropic, AMPA 4
  6. Target

    Succinate receptor 1

    go.drugbank.com/bio_entities/BE0002258
    TargetHumans

    G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, … Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well

    Polypeptides: Succinate receptor 1Synonyms: G protein-coupled receptor 91
  7. Target

    Neuromedin-K receptor

    go.drugbank.com/bio_entities/BE0002371
    TargetHumans

    Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:37391393). … Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity)

    Polypeptides: Neuromedin-K receptorSynonyms: NK-3 receptor, Neurokinin B receptor
  8. Target

    B2 bradykinin receptor

    go.drugbank.com/bio_entities/BE0003513
    TargetHumans

    Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: B2 bradykinin receptorSynonyms: BK-2 receptor
  9. Target

    Ryanodine receptor 3

    go.drugbank.com/bio_entities/BE0005296
    TransporterTargetHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed:12354756, PubMed:9395096). May...

    Polypeptides: Ryanodine receptor 3Synonyms: Type 3 ryanodine receptor, Brain-type ryanodine receptor
  10. Target

    5HT3 serotonin receptor

    go.drugbank.com/bio_entities/BE0005582
    TargetHumans

    Polypeptides: 5HT3 serotonin receptor