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Glimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalFirst introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: GLIMEPIRID HEUMANN 1MG NET, GLIMEPIRID HEUMANN 2MG NETOxycodone
go.drugbank.com/drugs/DB00497ApprovedIllicitInvestigationalOxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to seve...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: OXYCODON HEU 5 MG RET NET, OXYCODON HEU 10 MG RET NETGalantamine
go.drugbank.com/drugs/DB00674ApprovedInvestigationalGalantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the ear...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: GALANTAMIN HEU 8 MG NET, GALANTAMIN HEU 16 MG NETAlteplase
go.drugbank.com/drugs/DB00009ApprovedInvestigationalAlteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent.[L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots.
Mixtures: Activase RT-PA, Lysatec RT - PaSynonyms: t-PA, rt-PAIvabradine
go.drugbank.com/drugs/DB09083ApprovedInvestigationalIvabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: IVABRADIN HEU 5 MG NET, IVABRADIN HEU 7.5 MG NETDolutegravir
go.drugbank.com/drugs/DB08930ApprovedInvestigationalDolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent to...
Mixtures: Triumeq PDCategories: P-glycoprotein substratesNifedipine
go.drugbank.com/drugs/DB01115ApprovedInvestigationalNifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972....
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: Adalat Pa 20, Apo-nifed PaMethyl aminolevulinate
go.drugbank.com/drugs/DB00992ApprovedInvestigationalMethyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.
Products: KRX Aesthetics PD-13 TherapySimvastatin
go.drugbank.com/drugs/DB00641ApprovedInvestigationalSimvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk o...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: SIMVASTATIN HEU 10MG NET, SIMVASTATIN HEU 20MG NETAluminum chloride
go.drugbank.com/drugs/DB11081ApprovedInvestigationalAluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis ...
Products: Duradry PM, Clinical Strength MiracleDry Antiperspirant Deodorant PM