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Complex Partial Seizure Disorder
go.drugbank.com/conditions/DBCOND0038432Synonyms: Partial complex seizure, Complex partial SeizureNetarsudil
go.drugbank.com/drugs/DB13931ApprovedInvestigationalA Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous
High affinity cationic amino acid transporter 1
go.drugbank.com/bio_entities/BE0000212TargetTransporterHumansHigh-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues
Polypeptides: High affinity cationic amino acid transporter 1Synonyms: System Y+ basic amino acid transporterSodium- and chloride-dependent GABA transporter 1
go.drugbank.com/bio_entities/BE0000249TargetHumansCan also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity) … Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828).
Polypeptides: Sodium- and chloride-dependent GABA transporter 1Function: gamma-aminobutyric acid transmembrane transporter activitySodium- and chloride-dependent creatine transporter 1
go.drugbank.com/bio_entities/BE0000375TargetTransporterHumansCreatine:sodium symporter which mediates the uptake of creatine (PubMed:17465020, PubMed:22644605, PubMed:25861866, PubMed:7945388, PubMed:7953292, PubMed:9882430). Plays an important role in supplying creatine to the brain via the blood...
Polypeptides: Sodium- and chloride-dependent creatine transporter 1Synonyms: Creatine transporter 1Sodium- and chloride-dependent GABA transporter 2
go.drugbank.com/bio_entities/BE0004776TargetHumansMediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). … Can also mediate transport of taurine and hypotaurine (By similarity)
Polypeptides: Sodium- and chloride-dependent GABA transporter 2Function: amino acid transmembrane transporter activityLong-chain fatty acid transport protein 2
go.drugbank.com/bio_entities/BE0009868EnzymeHumansMediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:10198260, PubMed
Polypeptides: Long-chain fatty acid transport protein 2Synonyms: Fatty acid transport protein 2Large neutral amino acids transporter small subunit 2
go.drugbank.com/bio_entities/BE0000789TargetTransporterHumansAssociates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. … Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106).
Polypeptides: Large neutral amino acids transporter small subunit 2Synonyms: L-type amino acid transporter 2Solute carrier organic anion transporter family member 1B1
go.drugbank.com/bio_entities/BE0001004TransporterTargetCarrierHumansMay contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). … Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540).
Polypeptides: Solute carrier organic anion transporter family member 1B1Synonyms: Organic anion transporter SLC21A6, Liver-specific organic anion transporter 1Acetylcarnitine
go.drugbank.com/drugs/DB08842ApprovedInvestigationalThe main role of acetylcarnitine is to help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.