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Displaying results 4131 - 4140 of 10000 in total
  1. Drug

    Nabumetone

    go.drugbank.com/drugs/DB00461
    Approved

    [label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. … [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.

    Synonyms: 4-(6-Methoxy-2-naphthalenyl)-2-butanone, 4-(6-Methoxy-2-naphthyl)-2-butanoneMixtures: NuDroxiPAK N-500
  2. Drug

    Irofulven

    go.drugbank.com/drugs/DB05786
    Investigational

    A novel anti-cancer compound synthesized by scientists at the University of California, San Diego more than a decade ago from toxins of the poisonous jack-o-lantern mushroom, has been granted “fast track … Phase III clinical trials involving the drug have been underway since early 2001 at sites in the U.S. and Europe.

    Synonyms: 6-hydroxymethylacylfulvene
  3. Drug

    PZM21

    go.drugbank.com/drugs/DB14030
    Experimental

    PZM21 is a novel μ-opioid receptor (MOPr) ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ-opioid ligands

  4. Target

    Activated CDC42 kinase 1

    go.drugbank.com/bio_entities/BE0000772
    TargetHumans

    Contributes to the control of AXL receptor levels. … Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin.

    Synonyms: Tyrosine kinase non-receptor protein 2
  5. Drug

    Xylitol

    go.drugbank.com/drugs/DB11195
    ApprovedInvestigational

    The effects of xylitol on dental caries have been widely studied, and xylitol is added to some chewing gums and other oral care products to prevent tooth decay and dry mouth. … The recommended dose of xylitol for dental caries prevention is 6–10 g/day, and most adults can tolerate 40 g/day without adverse events [A22081].

    Synonyms: D-XylitolMixtures: Fluor-a-day, Fluor-a-day
  6. Drug

    Garadacimab

    go.drugbank.com/drugs/DB15629
    Approved

    [L53283,A273998] Garadacimab received its first approval in Australia and the UK in January 2025, and has since been approved in a number of other jurisdictions, including the EU and Japan. … Garadacimab is a fully human monoclonal antibody targeted against activated factor XII.

  7. Drug

    Retifanlimab

    go.drugbank.com/drugs/DB15766
    ApprovedInvestigational

    Retifanlimab is a humanized IgG4 kappa monoclonal antibody that binds to the programmed death receptor-1 (PD-1), blocking PD-1 interaction with its ligands, programmed death-ligand 1 (PD-L1) and programmed … [L45603,L45613] The use of retifanlimab in combination with other oncology drugs for the treatment of metastatic gastroesophageal adenocarcinoma has also been evaluated.[A258383,A258388]

    Synonyms: Anti-PD-1 monoclonal antibody MGA012Categories: Programmed Death Receptor-1 Blocking Antibody, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors
  8. Drug

    Pembrolizumab

    go.drugbank.com/drugs/DB09037
    ApprovedInvestigational

    [A7624] In the time since its initial approval, pembrolizumab has been granted approval in the treatment of a wide variety of cancers. … It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype containing a stabilizing S228P Fc mutation.

    Categories: Programmed Death Receptor-1 Blocking Antibody, Programmed Death Receptor-1-directed Antibody InteractionsProducts: KEYTRUDA® 100 MG, KEYTRUDA 100 MG/4 ML IV INFUZYONLUK COZELTI İÇEREN FLAKON, 1 ADET
  9. Target

    Suppressor of tumorigenicity 14 protein

    go.drugbank.com/bio_entities/BE0001656
    TargetHumans

    Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin ...

    Synonyms: Tumor-associated differentially-expressed gene 15 protein
  10. Target

    2-Hydroxyacid oxidase 2

    go.drugbank.com/bio_entities/BE0004577
    TargetEnzymeHumans

    Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the corresponding 2-oxoacids (PubMed:10777549). Its role in the oxidation of 2-hydroxy fatty acids may c...

    Synonyms: Cell growth-inhibiting gene 16 protein