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Displaying results 4191 - 4200 of 10000 in total
  1. Target

    Probable ATP-dependent 6-phosphofructokinase

    go.drugbank.com/bio_entities/BE0009180
    TargetPlasmodium falciparum (isolate 3D7)

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

    Polypeptides: Probable ATP-dependent 6-phosphofructokinaseFunction: 6-phosphofructokinase activity
  2. Target

    Ephrin type-B receptor 6

    go.drugbank.com/bio_entities/BE0009442
    TargetHumans

    Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation...

    Polypeptides: Ephrin type-B receptor 6Synonyms: Tyrosine-protein kinase-defective receptor EPH-6
  3. Target

    Growth arrest-specific protein 6

    go.drugbank.com/bio_entities/BE0010201
    TargetHumans

    Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell su...

    Polypeptides: Growth arrest-specific protein 6Synonyms: GAS-6
  4. Drug

    Aldesleukin

    go.drugbank.com/drugs/DB00041
    ApprovedInvestigational

    This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon … Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene.

    Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP3A InhibitorsSynonyms: 125-L-Serine-2-133-interleukin 2, 125-L-serine-2-133-interleukin 2 (human reduced)
  5. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0000455
    TargetHumans

    In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs (PubMed:10942115) … Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism (PubMed:10942115, PubMed:1339442, PubMed:34047349, PubMed:37794595).

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseSynonyms: 4-hydroxyphenylpyruvic acid oxidase, N(6)-adenosine-methyltransferase HPD
  6. Target

    Integrin alpha-4

    go.drugbank.com/bio_entities/BE0000590
    TargetHumans

    Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. … Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.

    Polypeptides: Integrin alpha-4Synonyms: VLA-4 subunit alpha
  7. Target

    Integrin beta-4

    go.drugbank.com/bio_entities/BE0003298
    TargetHumans

    Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

    Polypeptides: Integrin beta-4
  8. Target

    4-hydroxymandelate synthase

    go.drugbank.com/bio_entities/BE0004115
    TargetAmycolatopsis orientalis

    Required to synthesize hydroxyphenylglycine, a recurring skeletal component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin. Catalyzes the conversion of p-hydroxyphenylpyruvate to p-hydroxymandelate. The decarboxyl...

    Polypeptides: 4-hydroxymandelate synthaseSynonyms: 4-hydroxyphenylpyruvate dioxygenase II
  9. Target

    Phosphodiesterase isozyme 4

    go.drugbank.com/bio_entities/BE0009697
    TargetHumans

    Polypeptides: Phosphodiesterase isozyme 4
  10. Target

    P2Y purinoceptor 4

    go.drugbank.com/bio_entities/BE0009822
    TargetHumans

    Receptor for UTP and UDP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

    Polypeptides: P2Y purinoceptor 4