Search

Displaying results 4241 - 4250 of 10000 in total
  1. Target

    Dipeptidyl peptidase 4

    go.drugbank.com/bio_entities/BE0000854
    TargetEnzymeHumans

    Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth … When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790).

    Polypeptides: Dipeptidyl peptidase 4
  2. Target

    Platelet factor 4

    go.drugbank.com/bio_entities/BE0001129
    TargetHumans

    Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. … Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence (PubMed:9531587).

    Polypeptides: Platelet factor 4Synonyms: Oncostatin-A, PF-4
  3. Target

    Sphingomyelin phosphodiesterase 4

    go.drugbank.com/bio_entities/BE0002300
    TargetHumans

    It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489).

    Polypeptides: Sphingomyelin phosphodiesterase 4
  4. Target

    Histone deacetylase 4

    go.drugbank.com/bio_entities/BE0003523
    TargetHumans

    Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

    Polypeptides: Histone deacetylase 4
  5. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0004267
    TargetStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseFunction: 4-hydroxyphenylpyruvate dioxygenase activity
  6. Target

    P2X purinoceptor 4

    go.drugbank.com/bio_entities/BE0005793
    TargetHumans

    CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). … Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity).

    Polypeptides: P2X purinoceptor 4
  7. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis (PubMed:32327598, PubMed:33858992). … Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative

    Polypeptides: Melanocortin receptor 4
  8. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. … As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages.

    Polypeptides: Platelet glycoprotein 4Synonyms: PAS-4
  9. Drug

    Pertussis vaccine

    go.drugbank.com/drugs/DB15274
    ApprovedInvestigational

    Pertussis vaccine is under investigation in clinical trial NCT01698346 (Pertussis (Tdap) Vaccination in Pregnancy).

    Mixtures: Boostrix Injektionssuspension in einer Fertigspritze, dTaP Booster Injektionssuspension in einer FertigspritzeProducts: Pertussis Vaccine 4 Protect Unit
  10. Target

    Monocarboxylate transporter 4

    go.drugbank.com/bio_entities/BE0000449
    TargetTransporterHumans

    Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity)

    Polypeptides: Monocarboxylate transporter 4Synonyms: MCT 4