Search
Cation-independent mannose-6-phosphate receptor
go.drugbank.com/bio_entities/BE0003623TargetTransporterHumansLysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal
Polypeptides: Cation-independent mannose-6-phosphate receptorSynonyms: CI Man-6-P receptor, 300 kDa mannose 6-phosphate receptorSerine protease inhibitor Kazal-type 6
go.drugbank.com/bio_entities/BE0004563TargetHumansSerine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8
Polypeptides: Serine protease inhibitor Kazal-type 6ATP-dependent 6-phosphofructokinase, platelet type
go.drugbank.com/bio_entities/BE0013891TargetHumansCatalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Polypeptides: ATP-dependent 6-phosphofructokinase, platelet typeSynonyms: 6-phosphofructokinase type CPemetrexed
go.drugbank.com/drugs/DB00642ApprovedInvestigationalIts use in non-small cell lung cancer has also been investigated. Pemetrexed was first approved by the FDA in February 4, 2004.[A253907] … Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: PRELUN® 500 MG, MARTXEL® 100 MGSitagliptin
go.drugbank.com/drugs/DB01261ApprovedInvestigationalSitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].
Mixtures: M-sitagliptin-metformin, M-sitagliptin-metforminCategories: Drugs Used in Diabetes, Cytochrome P-450 Substrates4-aminobutyrate aminotransferase GabT
go.drugbank.com/bio_entities/BE0001510TargetEscherichia coli (strain K12)Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids. Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semia...
Polypeptides: 4-aminobutyrate aminotransferase GabTFunction: 4-aminobutyrate transaminase activityUDP-glucose 4-epimerase
go.drugbank.com/bio_entities/BE0001521TargetEnzymeHumansThe reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate.
Polypeptides: UDP-glucose 4-epimeraseSynonyms: UDP-GalNAc 4-epimerase, UDP-GlcNAc 4-epimerase4-hydroxy-tetrahydrodipicolinate reductase
go.drugbank.com/bio_entities/BE0001983TargetMycobacterium tuberculosisCatalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.
Polypeptides: 4-hydroxy-tetrahydrodipicolinate reductaseFunction: 4-hydroxy-tetrahydrodipicolinate reductaseCyclin-dependent kinase 4
go.drugbank.com/bio_entities/BE0002216TargetHumansSer/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows d...
Polypeptides: Cyclin-dependent kinase 4Synonyms: Cell division protein kinase 4Toll-like receptor 4
go.drugbank.com/bio_entities/BE0002442TargetHumansTransmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:10835634...
Polypeptides: Toll-like receptor 4