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Displaying results 421 - 430 of 531 in total
  1. Drug

    Midecamycin

    go.drugbank.com/drugs/DB13456
    Investigational

    Midecamycin is a naturally occurring 16-membered macrolide that fits under the category of acetoxy-substituted macrolide antibiotics. In this molecule, an acetoxy group is substituted on the position 9 of the 16-member ring and on positi...

  2. Drug

    Phenaridine

    go.drugbank.com/drugs/DB09178
    ExperimentalIllicit

    Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue

  3. Target

    Cartilage oligomeric matrix protein

    go.drugbank.com/bio_entities/BE0000899
    TargetHumans

    Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix...

    Synonyms: COMP
  4. Drug

    Tepotinib

    go.drugbank.com/drugs/DB15133
    ApprovedInvestigational

    In February 2022, tepotinib was approved for use in Europe.[L42200]

  5. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

    go.drugbank.com/bio_entities/BE0000081
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

    Synonyms: Complex I-42kD
  6. Target

    Calnexin

    go.drugbank.com/bio_entities/BE0001011
    TargetHumans

    Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation.

    Synonyms: Major histocompatibility complex class I antigen-binding protein p88
  7. Drug

    Linaclotide

    go.drugbank.com/drugs/DB08890
    ApprovedInvestigational

    Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist. Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activato...

  8. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

    go.drugbank.com/bio_entities/BE0000305
    TargetHumans

    Required for proper complex I assembly (PubMed:28671271). Complex I functions in the transfer of electrons from NADH to the respiratory chain. … Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.

    Synonyms: Complex I-39kD
  9. Target

    Nuclear factor of activated T-cells, cytoplasmic 1

    go.drugbank.com/bio_entities/BE0004878
    TargetHumans

    Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation a...

    Synonyms: NFAT transcription complex cytosolic component
  10. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

    go.drugbank.com/bio_entities/BE0000191
    TargetEnzymeHumans

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor … Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060)

    Synonyms: Complex I-30kD