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Cation-dependent mannose-6-phosphate receptor
go.drugbank.com/bio_entities/BE0004494TargetTransporterHumansLysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal
Polypeptides: Cation-dependent mannose-6-phosphate receptorSynonyms: CD Man-6-P receptor, 46 kDa mannose 6-phosphate receptorSerine/threonine-protein kinase PAK 6
go.drugbank.com/bio_entities/BE0009509TargetHumansSerine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR a...
Polypeptides: Serine/threonine-protein kinase PAK 6Synonyms: PAK-6, p21-activated kinase 6ATP-dependent 6-phosphofructokinase, muscle type
go.drugbank.com/bio_entities/BE0012586TargetHumansCatalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Polypeptides: ATP-dependent 6-phosphofructokinase, muscle typeSynonyms: 6-phosphofructokinase type AGlucose-6-phosphatase catalytic subunit 1
go.drugbank.com/bio_entities/BE0013006TargetHumansHydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. … Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis.
Polypeptides: Glucose-6-phosphatase catalytic subunit 1Synonyms: G-6-Pase, Glucose-6-phosphataseShort transient receptor potential channel 6
go.drugbank.com/bio_entities/BE0020965TargetHumansNon-selective, calcium-permeable cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholip...
Polypeptides: Short transient receptor potential channel 6Synonyms: TRP-6, Transient receptor protein 64-aminobutyrate aminotransferase, mitochondrial
go.drugbank.com/bio_entities/BE0000253TargetEnzymeHumansCatalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine...
Polypeptides: 4-aminobutyrate aminotransferase, mitochondrialRetinol-binding protein 4
go.drugbank.com/bio_entities/BE0000314CarrierTargetHumansRetinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates ...
Polypeptides: Retinol-binding protein 4Fibroblast growth factor 4
go.drugbank.com/bio_entities/BE0000326TargetHumansPlays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud d...
Polypeptides: Fibroblast growth factor 4Synonyms: FGF-4, HBGF-4Metabotropic glutamate receptor 4
go.drugbank.com/bio_entities/BE0000833TargetHumansG protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits ad...
Polypeptides: Metabotropic glutamate receptor 4Leukotriene A-4 hydrolase
go.drugbank.com/bio_entities/BE0001680TargetHumansBifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:1191...
Polypeptides: Leukotriene A-4 hydrolaseSynonyms: LTA-4 hydrolase, Leukotriene A(4) hydrolase