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Displaying results 4481 - 4490 of 10000 in total
  1. Drug

    Horseradish

    go.drugbank.com/drugs/DB10674
    Approved

    Horseradish allergenic extract is used in allergenic testing.

    Products: Nwk A-FV
  2. Target

    Cytotoxic T-lymphocyte protein 4

    go.drugbank.com/bio_entities/BE0000887
    TargetHumans

    Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). … Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501

    Polypeptides: Cytotoxic T-lymphocyte protein 4Synonyms: CTLA-4, Cytotoxic T-lymphocyte-associated antigen 4
  3. Target

    Protein-arginine deiminase type-4

    go.drugbank.com/bio_entities/BE0001092
    TargetHumans

    Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777 … Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin

    Polypeptides: Protein-arginine deiminase type-4
  4. Target

    Fibroblast growth factor receptor 4

    go.drugbank.com/bio_entities/BE0001203
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of

    Polypeptides: Fibroblast growth factor receptor 4Synonyms: FGFR-4
  5. Target

    dTDP-4-dehydrorhamnose 3,5-epimerase

    go.drugbank.com/bio_entities/BE0001669
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.

    Polypeptides: dTDP-4-dehydrorhamnose 3,5-epimeraseSynonyms: dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
  6. Target

    Choline transporter-like protein 4

    go.drugbank.com/bio_entities/BE0002182
    TransporterHumans

    Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function … Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed

    Polypeptides: Choline transporter-like protein 4Synonyms: Solute carrier family 44 member 4
  7. Target

    dTDP-4-dehydrorhamnose 3,5-epimerase

    go.drugbank.com/bio_entities/BE0002506
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.

    Polypeptides: dTDP-4-dehydrorhamnose 3,5-epimeraseSynonyms: dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
  8. Target

    dTDP-4-dehydrorhamnose 3,5-epimerase

    go.drugbank.com/bio_entities/BE0003322
    TargetMycobacterium tuberculosis

    Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. … peptidoglycan via a phosphodiester linkage.

    Polypeptides: dTDP-4-dehydrorhamnose 3,5-epimeraseSynonyms: dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
  9. Target

    DNA topoisomerase 4 subunit B

    go.drugbank.com/bio_entities/BE0003727
    TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

    Performs the decatenation events required during the replication of a circular DNA molecule.

    Polypeptides: DNA topoisomerase 4 subunit B
  10. Target

    Proteasome subunit beta type-4

    go.drugbank.com/bio_entities/BE0003918
    TargetHumans

    This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). … The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are

    Polypeptides: Proteasome subunit beta type-4