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dTDP-4-dehydrorhamnose 3,5-epimerase
go.drugbank.com/bio_entities/BE0003322TargetMycobacterium tuberculosisCatalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. … peptidoglycan via a phosphodiester linkage.
Polypeptides: dTDP-4-dehydrorhamnose 3,5-epimeraseSynonyms: dTDP-4-keto-6-deoxyglucose 3,5-epimerase, dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimeraseDNA topoisomerase 4 subunit B
go.drugbank.com/bio_entities/BE0003727TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)Performs the decatenation events required during the replication of a circular DNA molecule.
Polypeptides: DNA topoisomerase 4 subunit BProteasome subunit beta type-4
go.drugbank.com/bio_entities/BE0003918TargetHumansThis type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). … The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are
Polypeptides: Proteasome subunit beta type-4Pterin-4-alpha-carbinolamine dehydratase
go.drugbank.com/bio_entities/BE0004555TargetHumansAlso acts as a coactivator for HNF1B-dependent transcription (PubMed:24204001)
Polypeptides: Pterin-4-alpha-carbinolamine dehydrataseSynonyms: 4-alpha-hydroxy-tetrahydropterin dehydrataseIntracellular hyaluronan-binding protein 4
go.drugbank.com/bio_entities/BE0004943TargetHumansSeems to play a role in PML-nuclear bodies formation (PubMed:28695742). … Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity).
Polypeptides: Intracellular hyaluronan-binding protein 4Synonyms: IHABP-4, Hyaluronan-binding protein 4Immunoglobulin heavy constant gamma 4
go.drugbank.com/bio_entities/BE0005089TargetHumansIg gamma-4 (IgG4) isotype does not elicit antibody-dependent cellular cytotoxicity (ADDC) or complement-dependent cytotoxicity (CDC). … In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors, which upon binding to a specific antigen trigger the clonal expansion and differentiation of B lymphocytes into
Polypeptides: Immunoglobulin heavy constant gamma 4Synonyms: Ig gamma-4 chain C regionInward rectifier potassium channel 4
go.drugbank.com/bio_entities/BE0005187TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Polypeptides: Inward rectifier potassium channel 4Synonyms: Potassium channel, inwardly rectifying subfamily J member 4Calcium-dependent protein kinase 4
go.drugbank.com/bio_entities/BE0009256TargetPlasmodium falciparum (isolate 3D7)Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite. … Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141).
Polypeptides: Calcium-dependent protein kinase 4Sphingosine 1-phosphate receptor 4
go.drugbank.com/bio_entities/BE0009882TargetHumansFunctions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P).
Polypeptides: Sphingosine 1-phosphate receptor 4Synonyms: S1P receptor 4Ankle spasticity following a stroke or traumatic brain injury
go.drugbank.com/conditions/DBCOND0133858Drugs: Clostridium botulinumSynonyms: Ankle spasticity following a stroke or traumatic brain injury