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Displaying results 4571 - 4580 of 10000 in total
  1. Target

    Neuronal acetylcholine receptor subunit beta-4

    go.drugbank.com/bio_entities/BE0003584
    TargetHumans

    Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity) … acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a

    Polypeptides: Neuronal acetylcholine receptor subunit beta-4
  2. Target

    Interleukin-1 receptor-associated kinase 4

    go.drugbank.com/bio_entities/BE0004344
    TargetHumans

    Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. … Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections

    Polypeptides: Interleukin-1 receptor-associated kinase 4Synonyms: IRAK-4
  3. Target

    Ribosomal protein S6 kinase alpha-4

    go.drugbank.com/bio_entities/BE0004614
    TargetHumans

    Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activati...

    Polypeptides: Ribosomal protein S6 kinase alpha-4Synonyms: S6K-alpha-4, 90 kDa ribosomal protein S6 kinase 4
  4. Target

    Serine/threonine-protein kinase PAK 4

    go.drugbank.com/bio_entities/BE0009508
    TargetHumans

    Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival … Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues

    Polypeptides: Serine/threonine-protein kinase PAK 4Synonyms: PAK-4, p21-activated kinase 4
  5. Target

    C-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0009787
    TargetHumans

    Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival … The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: C-C chemokine receptor type 4Synonyms: CCR-4, CC-CKR-4
  6. Target

    Solute carrier family 13 member 4

    go.drugbank.com/bio_entities/BE0010199
    TransporterHumans

    Sodium:sulfate symporter that mediates sulfate reabsorption in the high endothelial venules (HEV)

    Polypeptides: Solute carrier family 13 member 4
  7. Target

    Short transient receptor potential channel 4

    go.drugbank.com/bio_entities/BE0020751
    TargetHumans

    Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). … Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314).

    Polypeptides: Short transient receptor potential channel 4Synonyms: hTrp-4, Trp-related protein 4
  8. Drug

    Trimetazidine

    go.drugbank.com/drugs/DB09069
    ApprovedInvestigational

    Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. … [L33015] Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride
  9. Indication

    Grade 1, grade 2, grade 3, grade 4 Urinary Tract Infection

    go.drugbank.com/conditions/DBCOND0128761
    Drugs: Amikacin · Cycloserine · Tetracycline
    Synonyms: Grade 4 Urinary Tract Infection, Grade 4 Urinary Tract Infections
  10. Target

    Neuronal acetylcholine receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000849
    TargetHumans

    acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-4