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Displaying results 4571 - 4580 of 10000 in total
  1. Target

    High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

    go.drugbank.com/bio_entities/BE0003134
    TargetHumans

    Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity...

    Polypeptides: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  2. Target

    Leucine-rich repeat-containing G protein-coupled receptor 5

    go.drugbank.com/bio_entities/BE0010835
    TargetHumans

    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with ph...

    Polypeptides: Leucine-rich repeat-containing G protein-coupled receptor 5
  3. Target

    Transient receptor potential cation channel subfamily M member 5

    go.drugbank.com/bio_entities/BE0020643
    TargetHumans

    Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated di...

    Polypeptides: Transient receptor potential cation channel subfamily M member 5Synonyms: LTrpC-5, Long transient receptor potential channel 5
  4. Drug

    Bifonazole

    go.drugbank.com/drugs/DB04794
    Approved

    Bifonazole is an azole antifungal drug.

    Mixtures: CANESTEN ULTRA UÑAS 1%Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2E1 Inhibitors
  5. Drug

    Dosulepin

    go.drugbank.com/drugs/DB09167
    ApprovedInvestigational

    It is not FDA-approved due to low therpeutic index and significant toxicity in overdose. … Dosulepin inhibits the reuptake of biogenic amines, increasing available neurotransmitter levels at the synaptic cleft.

    Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsSynonyms: (3E)-3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine, 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin
  6. Drug

    Telaprevir

    go.drugbank.com/drugs/DB05521
    ApprovedWithdrawn

    Telaprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotype 1 [FDA Label]. … Subtitutions at amino acid positions 155, 156, or 168 are known to confer resistance.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (1S,3aR,6aS)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide
  7. Drug

    Alanyl glutamine

    go.drugbank.com/drugs/DB11876
    Investigational

    Alanyl Glutamine is under investigation in clinical trial NCT00338221 (Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition).

    Synonyms: N(2)-L-Alanyl-L-glutamine, L-Alanyl-L-glutamineProducts: GLUTAVIVEN 20 G/100 ML IV INF. ICIN KONSANTRE COZELTI İÇEREN FLAKON, Kipo for IV Infusion 200 mg/ml
  8. Drug

    Tolperisone

    go.drugbank.com/drugs/DB06264
    Investigational

    It possesses a high affinity for nervous system tissue, reaching highest concentrations in brain stem, spinal cord and peripheral nerves. … Its precise mechanism is not completely understood, though it blocks sodium and calcium channels.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: TOLPERISON-NEURAX 50 MG, Netolp 50 mg Film Kaplı Tablet, 30 ADET
  9. Drug

    Manganese cation

    go.drugbank.com/drugs/DB06757
    ApprovedInvestigationalNutraceutical

    [A263687, A263662] In humans, manganese regulates several physiological processes by acting as a cofactor for proteins [A263657, A263662, A263667] making it an essential metal for normal development and … Manganese is a transition metal that was first described in the 19th and 20th centuries.

    Synonyms: MANGANESE(2+), MANGANESE ION(2+)Mixtures: TRACUTIL® 10 ML AMPOLLAS, Calcium With Mg Zn Mn Cu CR Si and Vit. C & D
  10. Pathway

    Acylcarnitine 10-Hydroxydodec-3-enedioylcarnitine

    smpdb.ca/view/SMP0124027
    Metabolic

    10-Hydroxydodec-3-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 10-hydroxydodec-3-enedioyl-CoA reacts with L-carnitine to form 10-hydroxydodec-3-enedioylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Solute carrier family 22 member 5