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Displaying results 451 - 460 of 10000 in total
  1. Pathway

    Phenylalanine and Tyrosine Metabolism

    smpdb.ca/view/SMP0000008
    Metabolic

    In order to split the aromatic ring of homogentisate, a further dioxygenase, homogentistate-oxygenase, is required to create maleylacetoacetate. … Fumarylacetate is created by the action maleylacetoacetate-cis-trans-isomerase through rotation of the carboxyl group created from the hydroxyl group via oxidation.

    Drugs: Pyridoxal phosphate · Phenylalanine · Adenosine phosphate · Tyrosine · Glutamic acid · ATP +11 more
  2. Pathway

    Arginine and Proline Metabolism

    smpdb.ca/view/SMP0000020
    Metabolic

    After this, the mitochondrial citrulline is released from the small intestine enterocytes and into the bloodstream where it is taken up by the kidneys for arginine production. … In particular, the amino acid citrulline is first synthesized from several other amino acids (glutamine, glutamate, and proline) in the mitochondria of the intestinal enterocytes (PMID: 9806879).

    Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 more
  3. Drug

    Tenofovir alafenamide

    go.drugbank.com/drugs/DB09299
    ApprovedInvestigational

    [T239] Tenofovir alafenamide is an alanine ester form characterized for presenting low systemic levels but high intracellular concentration. … [L4388,L9010] Tenofovir alafenamide was developed by Gilead Sciences Inc and granted FDA approval on 5 November 2015.[L6271]

    Mixtures: BIKTARVY FILM-COATED TABLETS 50MG/200MG/25MG, ODEFSEY FILM-COATED TABLET 200MG/25MG/25MGCategories: Tenofovir and prodrugs, Amino Acids, Peptides, and Proteins
  4. Drug

    Pindolol

    go.drugbank.com/drugs/DB00960
    ApprovedInvestigational

    [L32353] Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia.

    Categories: pindolol and other diureticsProducts: Apo-pindol Tab 10mg, Nu-pindol Tab 10mg
  5. Drug

    Iodine

    go.drugbank.com/drugs/DB05382
    ApprovedInvestigational

    Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. … Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.[A3413,A192153,A192156,A192159]

    Mixtures: Potassium and Iodine Tab, Potassium and Iodine TabCategories: Diet, Food, and Nutrition, Herbs and Natural Products
  6. Drug

    Leucovorin

    go.drugbank.com/drugs/DB00650
    ApprovedInvestigational

    anemias resulting from folate deficiency when oral therapy is not feasible. … [A275451] It is primarily indicated for "leucovorin rescue" to diminish the hematologic and mucosal toxicity of high-dose methotrexate therapy in osteosarcoma and to treat inadvertent overdoses of folic

    Categories: Enzymes and Coenzymes, Folic Acid and DerivativesProducts: Folina Tablets 15mg, Leucovorin Calcium Tab 5mg
  7. Drug

    Dolutegravir

    go.drugbank.com/drugs/DB08930
    ApprovedInvestigational

    [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. … [A7514] The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity.

    Mixtures: TRIUMEQ FILM COATED TABLET 50mg/600mg/300mgCategories: lamivudine and dolutegravir, dolutegravir and rilpivirine
  8. Drug

    Dorzolamide

    go.drugbank.com/drugs/DB00869
    ApprovedInvestigational

    [L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. … Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and

    Mixtures: DORZOLOL® UD, DORZOLAMIDE AND TIMOLOL STADA EYE DROPS 20MG/5MGCategories: latanoprost and dorzolamide, Antiglaucoma Preparations and Miotics
  9. Drug

    Dantrolene

    go.drugbank.com/drugs/DB01219
    ApprovedInvestigational

    Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.

    Categories: Dantrolene and DerivativesProducts: Dantrium Cap 25mg, Dantrium Cap 100mg
  10. Drug

    Ropinirole

    go.drugbank.com/drugs/DB00268
    ApprovedInvestigational

    In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome [A174547]. … In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous

    Products: REQUIP 1.0MG, REQUIP 1MG