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Displaying results 451 - 460 of 3599 in total
  1. Target

    Histamine H1 receptor

    go.drugbank.com/bio_entities/BE0000442
    TargetHumans

    G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). … Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules.

    Polypeptides: Histamine H1 receptorFunction: histamine receptor activity
  2. Target

    Ryanodine receptor 1

    go.drugbank.com/bio_entities/BE0000739
    TargetTransporterHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:...

    Polypeptides: Ryanodine receptor 1Synonyms: Type 1 ryanodine receptor, Skeletal muscle ryanodine receptor
  3. Target

    Thromboxane A2 receptor

    go.drugbank.com/bio_entities/BE0000759
    TargetHumans

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. … The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Thromboxane A2 receptorSynonyms: Prostanoid TP receptor
  4. Target

    Vasopressin V1b receptor

    go.drugbank.com/bio_entities/BE0000773
    TargetHumans

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system

    Polypeptides: Vasopressin V1b receptorSynonyms: Vasopressin V3 receptor, Antidiuretic hormone receptor 1b
  5. Target

    Neuropeptide S receptor

    go.drugbank.com/bio_entities/BE0000948
    TargetHumans

    G protein-coupled receptor for neuropeptide S (NPS) (PubMed:15947423, PubMed:16720571, PubMed:16790440). … In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (PubMed:26865629).

    Polypeptides: Neuropeptide S receptorSynonyms: G protein-coupled receptor 154, G protein-coupled receptor PGR14
  6. Target

    Histamine H3 receptor

    go.drugbank.com/bio_entities/BE0000968
    TargetHumans

    The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the abs...

    Polypeptides: Histamine H3 receptorSynonyms: G protein-coupled receptor 97
  7. Target

    Bile acid receptor

    go.drugbank.com/bio_entities/BE0001777
    TargetHumans

    Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). … 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands.

    Polypeptides: Bile acid receptorSynonyms: Farnesol receptor HRR-1, Farnesoid X-activated receptor
  8. Target

    Asialoglycoprotein receptor 2

    go.drugbank.com/bio_entities/BE0002118
    TargetHumans

    The receptor then returns to the cell membrane surface … After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated.

    Polypeptides: Asialoglycoprotein receptor 2Function: asialoglycoprotein receptor activity
  9. Target

    Angiopoietin-1 receptor

    go.drugbank.com/bio_entities/BE0003379
    TargetHumans

    The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1 … ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.

    Polypeptides: Angiopoietin-1 receptorSynonyms: Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2
  10. Target

    Folate receptor alpha

    go.drugbank.com/bio_entities/BE0003405
    TargetTransporterHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).

    Polypeptides: Folate receptor alphaSynonyms: Folate receptor 1, Folate receptor, adult