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Protein spire homolog 2
go.drugbank.com/bio_entities/BE0004157TargetHumansActs as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskel...
Polypeptides: Protein spire homolog 2Synonyms: Spir-2Penicillin-binding protein 2
go.drugbank.com/bio_entities/BE0004180TargetStaphylococcus aureus (strain COL)Polypeptides: Penicillin-binding protein 2Actin-related protein 2
go.drugbank.com/bio_entities/BE0004250TargetHumansATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin ne...
Polypeptides: Actin-related protein 2Synonyms: Actin-like protein 2SMAD family member 2
go.drugbank.com/bio_entities/BE0004445TargetHumansReceptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter regio...
Polypeptides: SMAD family member 2Synonyms: hMAD-2, SMAD 2Adenylate kinase 2, mitochondrial
go.drugbank.com/bio_entities/BE0004477TargetEnzymeHumansCatalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of t...
Polypeptides: Adenylate kinase 2, mitochondrialSynonyms: AK 2, ATP-AMP transphosphorylase 2Sterol O-acyltransferase 2
go.drugbank.com/bio_entities/BE0004608TargetEnzymeHumansCatalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:11294643, PubMed:16647063). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643)....
Polypeptides: Sterol O-acyltransferase 2Synonyms: ACAT-2, Cholesterol acyltransferase 2Parathyroid hormone 2 receptor
go.drugbank.com/bio_entities/BE0004703TargetHumansThis is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a si...
Polypeptides: Parathyroid hormone 2 receptorEquilibrative nucleoside transporter 2
go.drugbank.com/bio_entities/BE0004706TransporterTargetHumansBidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683...
Polypeptides: Equilibrative nucleoside transporter 2Synonyms: Solute carrier family 29 member 2Sodium/glucose cotransporter 2
go.drugbank.com/bio_entities/BE0004753TargetTransporterHumansElectrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Tran...
Polypeptides: Sodium/glucose cotransporter 2Synonyms: Na(+)/glucose cotransporter 2, Solute carrier family 5 member 2Sodium/nucleoside cotransporter 2
go.drugbank.com/bio_entities/BE0004781TransporterHumansSodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (Pub...
Polypeptides: Sodium/nucleoside cotransporter 2Synonyms: CNT 2, Na(+)/nucleoside cotransporter 2