Search
Tyrosine-protein phosphatase non-receptor type 4
go.drugbank.com/bio_entities/BE0000980TargetHumansPhosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 42-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
go.drugbank.com/bio_entities/BE0001450TargetEscherichia coli (strain K12)Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Polypeptides: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseFunction: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activitySodium/potassium-transporting ATPase subunit alpha-4
go.drugbank.com/bio_entities/BE0005031TransporterHumansSperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (P...
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-4Synonyms: Sodium pump subunit alpha-4, Na(+)/K(+) ATPase alpha-4 subunitSerine/threonine-protein phosphatase 4 catalytic subunit
go.drugbank.com/bio_entities/BE0013727TargetHumansThe PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.
Polypeptides: Serine/threonine-protein phosphatase 4 catalytic subunitExemestane
go.drugbank.com/drugs/DB00990ApprovedInvestigationalExemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal … It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: 6-methyleneandrosta-1,4-diene-3,17-dioneSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
go.drugbank.com/bio_entities/BE0000044TargetHumansAlso plays a role in the regulation of the endocytic trafficking of EGFR (By similarity) … Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity).
Polypeptides: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingLong-chain-fatty-acid--CoA ligase 4
go.drugbank.com/bio_entities/BE0000996TargetHumansCatalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233, PubMed:31061331, PubMed:387201...
Polypeptides: Long-chain-fatty-acid--CoA ligase 4Synonyms: LACS 4, Long-chain acyl-CoA synthetase 4Sodium channel protein type 4 subunit alpha
go.drugbank.com/bio_entities/BE0002083TargetTransporterHumansPore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.
Polypeptides: Sodium channel protein type 4 subunit alphaVery long chain fatty acid elongase 4
go.drugbank.com/bio_entities/BE0002247EnzymeTargetHumansMay play a critical role in early brain and skin development
Polypeptides: Very long chain fatty acid elongase 4Synonyms: ELOVL FA elongase 4, ELOVL fatty acid elongase 4Calcium-activated potassium channel subunit beta-4
go.drugbank.com/bio_entities/BE0004424TargetHumansRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium se...
Polypeptides: Calcium-activated potassium channel subunit beta-4Synonyms: Slo-beta-4, K(VCA)beta-4