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Displaying results 4691 - 4700 of 10000 in total
  1. Drug

    Risdiplam

    go.drugbank.com/drugs/DB15305
    ApprovedInvestigational

    [L15331,L15336] Set to be substantially cheaper than other available SMA therapies,[L15351] risdiplam appears to provide a novel and relatively accessible treatment option for patients with SMA regardless

    Categories: MATE 2 Inhibitors, Survival of Motor Neuron 2 Splicing ModifierProducts: Evrysdi Powder for oral solution 0.75 mg/mL, EVRYSDI POWDER FOR ORAL SOLUTION 0.75 MG/ML
  2. Target

    Tryptophan 5-hydroxylase 2

    go.drugbank.com/bio_entities/BE0000080
    EnzymeTargetHumans

    Neuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin

    Polypeptides: Tryptophan 5-hydroxylase 2Synonyms: Tryptophan 5-monooxygenase 2
  3. Target

    N-acylglucosamine 2-epimerase

    go.drugbank.com/bio_entities/BE0000109
    TargetEnzymeHumans

    Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:10502668, PubMed:12499362, PubMed:9990133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyz...

    Polypeptides: N-acylglucosamine 2-epimeraseSynonyms: GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase
  4. Target

    Apoptosis regulator Bcl-2

    go.drugbank.com/bio_entities/BE0000246
    TargetHumans

    Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368...

    Polypeptides: Apoptosis regulator Bcl-2
  5. Target

    Retinol-binding protein 2

    go.drugbank.com/bio_entities/BE0000505
    CarrierHumans

    Intracellular transport of retinol

    Polypeptides: Retinol-binding protein 2
  6. Target

    Beta-2 adrenergic receptor

    go.drugbank.com/bio_entities/BE0000694
    TargetHumans

    G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137). ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater aff...

    Polypeptides: Beta-2 adrenergic receptorSynonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptor
  7. Target

    Acetyl-CoA carboxylase 2

    go.drugbank.com/bio_entities/BE0000702
    TargetHumans

    Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated

    Polypeptides: Acetyl-CoA carboxylase 2
  8. Target

    DNA topoisomerase 2-alpha

    go.drugbank.com/bio_entities/BE0000742
    TargetHumans

    Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken st...

    Polypeptides: DNA topoisomerase 2-alpha
  9. Target

    Angiotensin-converting enzyme 2

    go.drugbank.com/bio_entities/BE0000982
    TargetEnzymeHumans

    Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin...

    Polypeptides: Angiotensin-converting enzyme 2
  10. Target

    Purine nucleoside phosphorylase 2

    go.drugbank.com/bio_entities/BE0001556
    TargetEscherichia coli (strain K12)

    The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This prot...

    Polypeptides: Purine nucleoside phosphorylase 2