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Displaying results 4801 - 4810 of 10000 in total
  1. Drug

    Tenofovir disoproxil

    go.drugbank.com/drugs/DB00300
    ApprovedInvestigational

    Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].

    Mixtures: TENOHOPE E (EMTRICITABINE 200 MG & TENOFOVIR DISOPROXIL FUMARATE 300 MG TABLETS), EMTRICITABINA E TENOFOVIR DISOPROXIL EGCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  2. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

    go.drugbank.com/bio_entities/BE0000500
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
  3. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase 2

    go.drugbank.com/bio_entities/BE0000585
    TargetEnzymeHumans

    Hence, it plays a central role in sexual differentiation and androgen physiology (PubMed:10898110) … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 2Function: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity
  4. Target

    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

    go.drugbank.com/bio_entities/BE0001574
    TargetShigella flexneri

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

    Polypeptides: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseSynonyms: 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
  5. Target

    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

    go.drugbank.com/bio_entities/BE0003931
    TargetHumans

    Synthesis and degradation of fructose 2,6-bisphosphate

    Polypeptides: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4Synonyms: PFK/FBPase 4, 6PF-2-K/Fru-2,6-P2ase 4
  6. Target

    Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

    go.drugbank.com/bio_entities/BE0003986
    TargetHumans

    The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix … Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit

    Polypeptides: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
  7. Target

    Dehydrogenase/reductase SDR family member 4-like 2

    go.drugbank.com/bio_entities/BE0004192
    TargetHumans

    Probable oxidoreductase

    Polypeptides: Dehydrogenase/reductase SDR family member 4-like 2
  8. Target

    Actin-related protein 2/3 complex subunit 4

    go.drugbank.com/bio_entities/BE0004254
    TargetHumans

    Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).

    Polypeptides: Actin-related protein 2/3 complex subunit 4
  9. Target

    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

    go.drugbank.com/bio_entities/BE0004284
    TargetHumans

    Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism … Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis.

    Polypeptides: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialSynonyms: Pyruvate dehydrogenase kinase isoform 4
  10. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

    go.drugbank.com/bio_entities/BE0009517
    TargetHumans

    PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism.

    Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaSynonyms: PI(5)P 4-kinase type II beta, PtdIns(5)P-4-kinase isoform 2-beta