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Hydroxyzine
go.drugbank.com/drugs/DB00557ApprovedInvestigationalHydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties. … [A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus
Mixtures: DOLMARAL®Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPentazocine
go.drugbank.com/drugs/DB00652ApprovedVet approvedIt is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Categories: P-glycoprotein substratesProducts: Pentazocine-Fresenius 30 mg/ml injection, Talwin - Liq 30mg/mlNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
go.drugbank.com/bio_entities/BE0000500TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...
Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial3-oxo-5-alpha-steroid 4-dehydrogenase 2
go.drugbank.com/bio_entities/BE0000585TargetEnzymeHumansHence, it plays a central role in sexual differentiation and androgen physiology (PubMed:10898110) … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 2Function: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
go.drugbank.com/bio_entities/BE0001574TargetShigella flexneriCatalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Polypeptides: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseSynonyms: 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
go.drugbank.com/bio_entities/BE0003931TargetHumansSynthesis and degradation of fructose 2,6-bisphosphate
Polypeptides: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4Synonyms: PFK/FBPase 4, 6PF-2-K/Fru-2,6-P2ase 4Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
go.drugbank.com/bio_entities/BE0003986TargetHumansThe BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix … Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit
Polypeptides: Cytochrome c oxidase subunit 4 isoform 1, mitochondrialDehydrogenase/reductase SDR family member 4-like 2
go.drugbank.com/bio_entities/BE0004192TargetHumansProbable oxidoreductase
Polypeptides: Dehydrogenase/reductase SDR family member 4-like 2Actin-related protein 2/3 complex subunit 4
go.drugbank.com/bio_entities/BE0004254TargetHumansActin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
Polypeptides: Actin-related protein 2/3 complex subunit 4[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
go.drugbank.com/bio_entities/BE0004284TargetHumansPlays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism … Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis.
Polypeptides: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialSynonyms: Pyruvate dehydrogenase kinase isoform 4