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Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
go.drugbank.com/bio_entities/BE0004522TargetTransporterHumansRegulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity) … calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity).
Polypeptides: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1Function: calcium channel inhibitor activityVoltage-dependent P/Q-type calcium channel
go.drugbank.com/bio_entities/BE0008717TransporterTargetHumansThe isoform alpha-1A gives rise to P and/or Q-type calcium currents. … Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone
Polypeptides: Voltage-dependent P/Q-type calcium channel subunit alpha-1ASynonyms: Brain calcium channel I, Voltage-gated calcium channel subunit alpha Cav2.1Calcium/calmodulin-dependent protein kinase kinase 2
go.drugbank.com/bio_entities/BE0009419TargetHumansCalcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. … Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive.
Polypeptides: Calcium/calmodulin-dependent protein kinase kinase 2Synonyms: Calcium/calmodulin-dependent protein kinase kinase betaInositol 1,4,5-trisphosphate-gated calcium channel ITPR2
go.drugbank.com/bio_entities/BE0009594TargetHumansInositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. … Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state
Polypeptides: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2Function: calcium ion bindingInositol 1,4,5-trisphosphate-gated calcium channel ITPR3
go.drugbank.com/bio_entities/BE0009595TargetHumanscalcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584, PubMed:39560673). 1D-myo-inositol 1,4,5-trisphosphate binds to … Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed
Polypeptides: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR385/88 kDa calcium-independent phospholipase A2
go.drugbank.com/bio_entities/BE0001077TargetHumansCalcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. … In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity)
Polypeptides: 85/88 kDa calcium-independent phospholipase A2Synonyms: Intracellular membrane-associated calcium-independent phospholipase A2 betaCalcium-activated potassium channel subunit beta-2
go.drugbank.com/bio_entities/BE0003196TargetHumansRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. … Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex.
Polypeptides: Calcium-activated potassium channel subunit beta-2Synonyms: Calcium-activated potassium channel, subfamily M subunit beta-2Calcium/calmodulin-dependent protein kinase type IV
go.drugbank.com/bio_entities/BE0004042TargetHumansCalcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators … Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2.
Polypeptides: Calcium/calmodulin-dependent protein kinase type IVCalcium-activated potassium channel subunit beta-4
go.drugbank.com/bio_entities/BE0004424TargetHumansDecreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. … Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.
Polypeptides: Calcium-activated potassium channel subunit beta-4Synonyms: Calcium-activated potassium channel, subfamily M subunit beta-4Voltage-dependent calcium channel gamma-2 subunit
go.drugbank.com/bio_entities/BE0005108TargetHumansDoes not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state … Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization.
Polypeptides: Voltage-dependent calcium channel gamma-2 subunitSynonyms: Neuronal voltage-gated calcium channel gamma-2 subunit