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Displaying results 41 - 50 of 453 in total
  1. Target

    Fatty-acid peroxygenase

    go.drugbank.com/bio_entities/BE0001960
    TargetEnzymeBacillus subtilis (strain 168)

    Catalyzes the alpha- and beta-hydroxylation of myristic acid in the presence of hydrogen peroxide.

    Polypeptides: Fatty-acid peroxygenaseSynonyms: Fatty acid beta-hydroxylase
  2. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis … These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity).

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  3. Target

    Zinc finger and BTB domain-containing protein 7A

    go.drugbank.com/bio_entities/BE0012406
    TargetHumans

    Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription … That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493).

    Polypeptides: Zinc finger and BTB domain-containing protein 7ASynonyms: POZ and Krueppel erythroid myeloid ontogenic factor, Factor that binds to inducer of short transcripts protein 1
  4. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 4

    go.drugbank.com/bio_entities/BE0004687
    EnzymeTargetHumans

    Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). … May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4
  5. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 13

    go.drugbank.com/bio_entities/BE0009336
    EnzymeTargetHumans

    Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13
  6. Target

    T-cell immunoreceptor with Ig and ITIM domains

    go.drugbank.com/bio_entities/BE0010742
    TargetHumans

    Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D … In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388).

    Polypeptides: T-cell immunoreceptor with Ig and ITIM domainsSynonyms: V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3
  7. Target

    Lysosomal acid glucosylceramidase

    go.drugbank.com/bio_entities/BE0000978
    TargetEnzymeHumans

    Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation … Plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698).

    Polypeptides: Lysosomal acid glucosylceramidaseSynonyms: Acid beta-glucosidase, Lysosomal acid GCase
  8. Target

    Testicular acid phosphatase

    go.drugbank.com/bio_entities/BE0019349
    TargetHumans

    Regulates odontoblast cell fate via its extracellular catalytic domain by inhibiting proliferation and promoting differentiation (By similarity)

    Polypeptides: Testicular acid phosphataseSynonyms: Acid phosphatase 4
  9. Target

    Probable fatty acid synthase Fas (Fatty acid synthetase)

    go.drugbank.com/bio_entities/BE0009744
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Polypeptides: Probable fatty acid synthase Fas (Fatty acid synthetase)
  10. Target

    Prostatic acid phosphatase

    go.drugbank.com/bio_entities/BE0001102
    TargetHumans

    Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042) … A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins

    Polypeptides: Prostatic acid phosphataseSynonyms: Acid phosphatase 3