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Displaying results 41 - 50 of 298 in total
  1. Target

    Insulin-degrading enzyme

    go.drugbank.com/bio_entities/BE0001183
    TargetEnzymeHumans

    Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). … Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide

    Polypeptides: Insulin-degrading enzymeSynonyms: Insulin protease, Insulinase
  2. Target

    Insulin receptor substrate 1

    go.drugbank.com/bio_entities/BE0000977
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 1Function: insulin receptor binding
  3. Target

    Insulin receptor substrate 2

    go.drugbank.com/bio_entities/BE0021286
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 2
  4. Target

    Insulin receptor-related protein

    go.drugbank.com/bio_entities/BE0009451
    TargetHumans

    Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB

    Polypeptides: Insulin receptor-related protein
  5. Target

    Insulin-induced gene 2 protein

    go.drugbank.com/bio_entities/BE0021304
    TargetHumans

    Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as ...

    Polypeptides: Insulin-induced gene 2 protein
  6. Target

    Insulin-like growth factor 1

    go.drugbank.com/bio_entities/BE0003418
    TargetHumans

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. … Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to

    Polypeptides: Insulin-like growth factor 1Synonyms: Insulin-like growth factor I
  7. Target

    Insulin-like growth factor 2

    go.drugbank.com/bio_entities/BE0010370
    TargetHumans

    The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development.

    Polypeptides: Insulin-like growth factor 2Synonyms: Insulin-like growth factor II
  8. Target

    Insulin-induced gene 1 protein

    go.drugbank.com/bio_entities/BE0011639
    TargetHumans

    Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16...

    Polypeptides: Insulin-induced gene 1 protein
  9. Target

    Insulin-like growth factor-binding protein 1

    go.drugbank.com/bio_entities/BE0009658
    CarrierHumans

    Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentia...

    Polypeptides: Insulin-like growth factor-binding protein 1Function: insulin-like growth factor binding
  10. Target

    Insulin-like growth factor-binding protein 4

    go.drugbank.com/bio_entities/BE0009660
    CarrierHumans

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

    Polypeptides: Insulin-like growth factor-binding protein 4Function: insulin-like growth factor I binding