Search

Displaying results 41 - 50 of 178 in total
  1. Target

    Alpha-2A adrenergic receptor

    go.drugbank.com/bio_entities/BE0000289
    TargetHumans

    Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2568356, PubMed:27376152).

  2. Target

    ALK tyrosine kinase receptor

    go.drugbank.com/bio_entities/BE0000359
    TargetHumans

    MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction

  3. Target

    Putative hydrolase DDAH2

    go.drugbank.com/bio_entities/BE0000608
    TargetHumans

    Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity).

  4. Target

    Monocarboxylate transporter 1

    go.drugbank.com/bio_entities/BE0000669
    TargetTransporterHumans

    concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). … Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with

  5. Target

    5'-AMP-activated protein kinase catalytic subunit alpha-1

    go.drugbank.com/bio_entities/BE0000677
    TargetHumans

    Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity).

  6. Target

    Tumor necrosis factor

    go.drugbank.com/bio_entities/BE0000704
    TargetHumans

    Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. … Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).

  7. Target

    Glucagon-like peptide 1 receptor

    go.drugbank.com/bio_entities/BE0000857
    TargetHumans

    Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)

  8. Target

    Alpha-1-antitrypsin

    go.drugbank.com/bio_entities/BE0000952
    TargetCarrierHumans

    The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin

  9. Target

    Phosphatidylinositol 3-kinase regulatory subunit alpha

    go.drugbank.com/bio_entities/BE0000955
    TargetHumans

    Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. … Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays

  10. Target

    C-C motif chemokine 5

    go.drugbank.com/bio_entities/BE0000975
    TargetHumans

    By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485)