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Displaying results 501 - 510 of 10000 in total
  1. Target

    Oncostatin-M-specific receptor subunit beta

    go.drugbank.com/bio_entities/BE0018846
    TargetHumans

    Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer composed of OSMR and IL31RA)...

    Synonyms: IL-31RB, IL-31R-beta
  2. Target

    Interleukin-23 subunit alpha

    go.drugbank.com/bio_entities/BE0003415
    TargetHumans

    Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044) … Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383).

    Synonyms: IL-23-A, IL-23p19
  3. Target

    Interleukin-17 receptor A

    go.drugbank.com/bio_entities/BE0018249
    TargetHumans

    Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL...

    Synonyms: IL-17RA, IL-17 receptor A
  4. Target

    Interleukin-15

    go.drugbank.com/bio_entities/BE0003486
    TargetHumans

    Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulat...

    Synonyms: IL-15
  5. Drug

    Temozolomide

    go.drugbank.com/drugs/DB00853
    ApprovedInvestigational

    It is currently marketed under the trademark TEMODAR® by Merck.[L32033] … [A229848, A229858, L32033] Temozolomide is an imidazotetrazine prodrug that is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH; these properties allow

    Products: TEMODAL ® IV, TEMODAL 140MG HKP IN BTL
  6. Drug

    Bevacizumab

    go.drugbank.com/drugs/DB00112
    ApprovedInvestigational

    There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells. … bevacizumab a therapeutic role in both oncology and ophthalmology.

    Products: BEVAX 100MG/4 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET, BEVAX 400MG/16 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET
  7. Drug

    Vinblastine

    go.drugbank.com/drugs/DB00570
    ApprovedInvestigational

    Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

    Products: VINKO 1 MG/ML IV INFÜZYON ICIN COZELTİ ICEREN FLAKON, 1 ADET, Velbe 1mg/ml
  8. Target

    Interleukin-17 receptor B

    go.drugbank.com/bio_entities/BE0020027
    TargetHumans

    Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells

    Synonyms: IL-17RB, IL-17Rh1
  9. Target

    Interleukin-1 receptor accessory protein

    go.drugbank.com/bio_entities/BE0010488
    TargetHumans

    Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. … Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).

    Synonyms: IL-1R3, IL-1R-3
  10. Drug

    Daunorubicin

    go.drugbank.com/drugs/DB00694
    ApprovedInvestigational

    A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.

    Synonyms: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedioneCategories: Topoisomerase II Inhibitors