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Displaying results 501 - 510 of 3730 in total
  1. Target

    Angiopoietin-1 receptor

    go.drugbank.com/bio_entities/BE0003379
    TargetHumans

    The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1 … ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.

    Polypeptides: Angiopoietin-1 receptorSynonyms: Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2
  2. Target

    Folate receptor alpha

    go.drugbank.com/bio_entities/BE0003405
    TargetTransporterHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).

    Polypeptides: Folate receptor alphaSynonyms: Folate receptor 1, Folate receptor, adult
  3. Target

    Beta adrenergic receptor

    go.drugbank.com/bio_entities/BE0004872
    TargetHumans

    Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2 (PubMed:12391161). … G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137).

    Polypeptides: Beta-1 adrenergic receptor, Beta-2 adrenergic receptorFunction: alpha-2A adrenergic receptor binding, beta-adrenergic receptor activity
  4. Target

    Muscarinic acetylcholine receptor

    go.drugbank.com/bio_entities/BE0004890
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613).

    Polypeptides: Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2Function: G protein-coupled acetylcholine receptor activity, G protein-coupled acetylcholine receptor activity
  5. Target

    Macrophage receptor MARCO

    go.drugbank.com/bio_entities/BE0009001
    TargetHumans

    Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508).

    Polypeptides: Macrophage receptor MARCOSynonyms: Scavenger receptor class A member 2, Macrophage receptor with collagenous structure
  6. Target

    Histamine H1 receptor

    go.drugbank.com/bio_entities/BE0009144
    CarrierTargetMouse

    In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well ...

    Polypeptides: Histamine H1 receptor
  7. Target

    Dopamine receptor D2

    go.drugbank.com/bio_entities/BE0009377
    TargetRat

    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:1321233). … Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).

    Polypeptides: Dopamine receptor D2Synonyms: Dopamine D2 receptor, D(2) dopamine receptor
  8. Target

    Melanocortin receptor 3

    go.drugbank.com/bio_entities/BE0009683
    TargetHumans

    G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8463333).

    Polypeptides: Melanocortin receptor 3Function: corticotropin receptor activity
  9. Target

    Asialoglycoprotein receptor 1

    go.drugbank.com/bio_entities/BE0010188
    TargetCarrierTransporterHumans

    Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface … Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway (PubMed:25485912).

    Polypeptides: Asialoglycoprotein receptor 1Function: asialoglycoprotein receptor activity
  10. Target

    GABA(B) Receptor

    go.drugbank.com/bio_entities/BE0010194
    Target

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase ( … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 1, GABA-B receptor 2