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Vascular endothelial growth factor receptor 2
go.drugbank.com/bio_entities/BE0000369TargetHumansIsoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. … Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4.
Polypeptides: Vascular endothelial growth factor receptor 2Synonyms: VEGFR-2Taste receptor type 1 member 2
go.drugbank.com/bio_entities/BE0000395TargetHumansKey component of the sweet taste receptor (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). TAS1R2 and TAS1R3 form the sweet taste receptor and recognize diverse natural and synthetic sweeteners (PubMed:11917125, PubM...
Polypeptides: Taste receptor type 1 member 2Neuronal acetylcholine receptor subunit beta-2
go.drugbank.com/bio_entities/BE0000850TargetHumansFound in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation
Polypeptides: Neuronal acetylcholine receptor subunit beta-2Prolyl 4-hydroxylase subunit alpha-2
go.drugbank.com/bio_entities/BE0002253TargetHumansCatalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins
Polypeptides: Prolyl 4-hydroxylase subunit alpha-2Synonyms: 4-PH alpha-2, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2Glycine N-acyltransferase-like protein 2
go.drugbank.com/bio_entities/BE0002306TargetHumansMitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine (PubMed:20305126, PubMed:22475485). Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging ...
Polypeptides: Glycine N-acyltransferase-like protein 2Synonyms: Acyl-CoA:glycine N-acyltransferase-like protein 2Peroxisomal trans-2-enoyl-CoA reductase
go.drugbank.com/bio_entities/BE0002791TargetHumansCatalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity
Polypeptides: Peroxisomal trans-2-enoyl-CoA reductaseC-C chemokine receptor type 2
go.drugbank.com/bio_entities/BE0003387TargetHumansKey functional receptor for CCL2 but can also bind CCL7, and CCL12 (PubMed:23408426, PubMed:38157855, PubMed:8048929, PubMed:8146186). Also transduces signaling mediated by CCL13 (PubMed:38157855). Its binding with CCL2 on monocytes and ...
Polypeptides: C-C chemokine receptor type 2Synonyms: CCR-2, CC-CKR-2Transforming growth factor beta-2 proprotein
go.drugbank.com/bio_entities/BE0003481TargetHumansPrecursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively
Polypeptides: Transforming growth factor beta-2 proproteinGuanylate cyclase soluble subunit alpha-2
go.drugbank.com/bio_entities/BE0003578TargetEnzymeHumansAlpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby tra...
Polypeptides: Guanylate cyclase soluble subunit alpha-2Synonyms: GCS-alpha-2Solute carrier family 22 member 2
go.drugbank.com/bio_entities/BE0003647TransporterCarrierHumansElectrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9687576). Functions as a Na(+)-independent, ...
Polypeptides: Solute carrier family 22 member 2Synonyms: Organic cation transporter 2