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Displaying results 511 - 520 of 10000 in total
  1. Drug

    Darunavir

    go.drugbank.com/drugs/DB01264
    ApprovedInvestigational

    Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as [ritonavir] for the effective management of HIV-1 infection. … [L9227] Darunavir is being studied as a possible treatment for SARS-CoV-2, the coronavirus responsible for COVID-19, due to in vitro evidence supporting its ability to combat this infection.

    Mixtures: FURTHAS®R TABLETAS RECUBIERTAS, PREZCOBIX® TABLETAS RECUBIERTASCategories: P-glycoprotein inducers, P-glycoprotein inhibitors
  2. Drug

    Prasterone sulfate

    go.drugbank.com/drugs/DB05804
    Investigational

    DHEA-S is elevated with hyperprolactinemia. … DHEA sulfate is the major steroid of the fetal adrenal. DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin.

    Categories: Cytochrome P-450 CYP3A7 SubstratesSynonyms: DHEA-S, (3-beta)-3-(Sulfooxy)androst-5-en-17-one
  3. Pathway

    S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

    smpdb.ca/view/SMP0125680
    Disease

    AHCY codes for the enzyme S-adenosylhomocysteine hydrolase (AdoHcyase) which efficiently eliminates S-adenosylhomocysteine (SAH) by catalyzing its hydrolysis into adenosine and homocysteine. … SAH is both a byproduct of S-adenosylmethionine-dependent methyltransferases and a powerful methyltransferase inhibitor.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  4. Drug

    Testosterone

    go.drugbank.com/drugs/DB00624
    ApprovedInvestigational

    Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.

    Categories: 3-Oxoandrosten (4) Derivatives, P-glycoprotein inhibitorsSynonyms: 4-androsten-17β-ol-3-one, 17beta-hydroxy-4-androsten-3-one
  5. Drug

    Olea europaea pollen

    go.drugbank.com/drugs/DB10378
    Approved

    Olea europaea pollen is the pollen of the Olea europaea plant. Olea europaea pollen is mainly used in allergenic testing.

    Mixtures: Western 3 Tree Pollen Mix, Western 3 Tree Pollen MixSynonyms: Olea europaea pollen, european olive pollen extract
  6. Pathway

    S-Adenosylhomocysteine (SAH) Hydrolase Deficiency

    smpdb.ca/view/SMP0000214
    Disease

    AHCY codes for the enzyme S-adenosylhomocysteine hydrolase (AdoHcyase) which efficiently eliminates S-adenosylhomocysteine (SAH) by catalyzing its hydrolysis into adenosine and homocysteine. … SAH is both a byproduct of S-adenosylmethionine-dependent methyltransferases and a powerful methyltransferase inhibitor.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  7. Drug

    XPro1595

    go.drugbank.com/drugs/DB16454
    Investigational

    XPro1595 is an investigational dominant-negative protein that neutralizes soluble TNF.

    Synonyms: HOMOSAPIENS TUMOR NECROSIS FACTOR,SOLUBLE FORM (V1>M, R31>C, C69>V, Y87>H, C101>A, A145>R), MONOMER, PEGYLATED ON CYSTEINE 31 : S-((3RS)-(2-((3-(.OMEGA., SOLUBLE TUMOR NECROSIS FACTOR (1-METHIONINE,31-CYSTEINE,69-VALINE,87-HISTIDINE,101-ALANINE,145-ARGININE) (HUMAN CONSTRUCT XPRO1595), 31-THIOETHER WITH .ALPHA.-(3-((3-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDINYL
  8. Pathway

    Metabolism and Physiological Effects of S-Adenosylhomocysteine

    smpdb.ca/view/SMP0127690
    Metabolic

    S-Adenosyl-L-homocysteine (SAH) is formed by the demethylation of S-adenosyl-L-methionine. … S-Adenosylhomocysteine forms when there are elevated levels of homocysteine and adenosine. S-Adenosyl-L-homocysteine is a potent inhibitor of S-adenosyl-L-methionine-dependent methylation reactions.

    Drugs: Ademetionine · Methionine · ATP · Potassium cation · Magnesium cation · Pyrophosphoric acid
    Enzymes: S-methylmethionine--homocysteine S-methyltransferase BHMT2, S-adenosylmethionine synthase isoform type-2
  9. Drug

    TD-0903

    go.drugbank.com/drugs/DB16463
    Investigational

    TD-0903 was investigated in clinical trials for its potential to treat acute lung injury (ALI) associated with COVID-19, including NCT04350736, NCT05091723 (a pharmacokinetics study in healthy participants

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: (S)-(3-(DIMETHYLAMINO)AZETIDIN-1-YL)(2-(6-(2-ETHYL-4-HYDROXYPHENYL)-1H-INDAZOL-3-YL)-5-ISOPROPYL-4,5,6,7-TETRAHYDRO-3H-IMIDAZO(4,5-C)PYRIDIN-6-YL)METHANONE, (3-(DIMETHYLAMINO)AZETIDIN-1-YL)((6S)-2-(6-(2-ETHYL-4-HYDROXYPHENYL)-1H-INDAZOL-3-YL)-5-(PROPAN-2-YL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZO(4,5-C)PYRIDIN-6-YL)METHANONE
  10. Drug

    Dapiglutide

    go.drugbank.com/drugs/DB19182
    Investigational

    Dapiglutide is under investigation in clinical trial NCT05788601 (Dapiglutide for the Treatment of Obesity).

    Synonyms: -glutamyl)- (a2>aib (2-methylalanine), d3>e, s7>t, d8>s, m10>l, n11>a, n16>k, l17>q, n24>a, t29>h)human glucagonlike peptide 2 (glp-2), L-ASPARTIC ACID, L-HISTIDYL-2-METHYLALANYL-L-.ALPHA.-GLUTAMYLGLYCYL-L-SERYL-L-PHENYLALANYL-L-THREONYL-L-SERYL-L-.ALPHA.-GLUTAMYL-L-LEUCYL-L-ALANYL-L-THREONYL-L-ISOLEUCYL-L-LEUCYL-L-.ALPHA.