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Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
go.drugbank.com/bio_entities/BE0000087TargetHumansPart of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine r...
Polypeptides: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Gamma-aminobutyric acid receptor subunit alpha-2
go.drugbank.com/bio_entities/BE0000381TargetHumansThe alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABAAR subunit alpha-2, GABA(A) receptor subunit alpha-2Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
go.drugbank.com/bio_entities/BE0001402TargetVACVAt the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap.
Polypeptides: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferaseFunction: mRNA (nucleoside-2'-O-)-methyltransferase activityGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
go.drugbank.com/bio_entities/BE0002238EnzymeHumansRate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:35229715...
Polypeptides: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2Synonyms: GFAT 2, Hexosephosphate aminotransferase 2Calcium-activated potassium channel subunit beta-2
go.drugbank.com/bio_entities/BE0003196TargetHumansRegulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers ra...
Polypeptides: Calcium-activated potassium channel subunit beta-2Synonyms: Slo-beta-2, K(VCA)beta-2Cytochrome b-c1 complex subunit 2, mitochondrial
go.drugbank.com/bio_entities/BE0003855TargetHumansIn the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). … The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP
Polypeptides: Cytochrome b-c1 complex subunit 2, mitochondrialSynonyms: Complex III subunit 2, Ubiquinol-cytochrome-c reductase complex core protein 2Sodium/potassium-transporting ATPase subunit beta-2
go.drugbank.com/bio_entities/BE0005018TransporterTargetHumansThe exact function of the beta-2 subunit is not known
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-2Synonyms: Sodium/potassium-dependent ATPase subunit beta-2Voltage-dependent calcium channel gamma-2 subunit
go.drugbank.com/bio_entities/BE0005108TargetHumansRegulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deacti...
Polypeptides: Voltage-dependent calcium channel gamma-2 subunitSynonyms: TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2Serine/threonine-protein kinase tousled-like 2
go.drugbank.com/bio_entities/BE0009398TargetHumansSerine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMe...
Polypeptides: Serine/threonine-protein kinase tousled-like 2Synonyms: Tousled-like kinase 2POU domain, class 2, transcription factor 1
go.drugbank.com/bio_entities/BE0009712TransporterHumansTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription tr...
Polypeptides: POU domain, class 2, transcription factor 1