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Displaying results 521 - 530 of 1709 in total
  1. Target

    Hepatocyte growth factor receptor

    go.drugbank.com/bio_entities/BE0000915
    TargetHumans

    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.

    Polypeptides: Hepatocyte growth factor receptorSynonyms: HGF receptor, SF receptor
  2. Target

    Endothelial protein C receptor

    go.drugbank.com/bio_entities/BE0001161
    TargetHumans

    Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation

    Polypeptides: Endothelial protein C receptorSynonyms: APC receptor, Activated protein C receptor
  3. Target

    Toll-like receptor 2

    go.drugbank.com/bio_entities/BE0001164
    TargetHumans

    MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). … Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205).

    Polypeptides: Toll-like receptor 2Synonyms: Toll/interleukin-1 receptor-like protein 4
  4. Target

    Metabotropic glutamate receptor 5

    go.drugbank.com/bio_entities/BE0001192
    TargetHumans

    G protein-coupled receptor for glutamate.

    Polypeptides: Metabotropic glutamate receptor 5Function: A2A adenosine receptor binding
  5. Target

    N-arachidonyl glycine receptor

    go.drugbank.com/bio_entities/BE0002304
    TargetHumans

    CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over … G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems (PubMed:21732409, PubMed:26195725).

    Polypeptides: N-arachidonyl glycine receptorSynonyms: NAGly receptor, G protein-coupled receptor 18
  6. Target

    Anthrax toxin receptor 1

    go.drugbank.com/bio_entities/BE0003447
    TargetHumans

    May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478)

    Polypeptides: Anthrax toxin receptor 1
  7. Target

    Toll-like receptor 8

    go.drugbank.com/bio_entities/BE0003518
    TargetHumans

    Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612).

    Polypeptides: Toll-like receptor 8
  8. Target

    Somatostatin receptor type 3

    go.drugbank.com/bio_entities/BE0003529
    TargetHumans

    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase

    Polypeptides: Somatostatin receptor type 3Function: G protein-coupled receptor activity
  9. Target

    Nuclear receptor ROR-beta

    go.drugbank.com/bio_entities/BE0003554
    TargetHumans

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.

    Polypeptides: Nuclear receptor ROR-betaSynonyms: Nuclear receptor RZR-beta, Retinoid-related orphan receptor-beta
  10. Target

    Oxysterols receptor LXR-alpha

    go.drugbank.com/bio_entities/BE0003781
    TargetHumans

    Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). … Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by

    Polypeptides: Oxysterols receptor LXR-alphaSynonyms: Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3