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Erdafitinib
go.drugbank.com/drugs/DB12147ApprovedInvestigationaltool kit to treat such a prevalent medical condition. … [L5956, L5959] At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: BALVERSA 5 MG FİLM KAPLI TABLET, 28 ADET, BALVERSA 4 MG FİLM KAPLI TABLET, 28 ADETInvasive Infection caused by Streptococcus pneumoniae serotype 5
go.drugbank.com/conditions/DBCOND0093623Drugs: Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigenSynonyms: Invasive Infection caused by Streptococcus pneumoniae serotype 5Hexetidine
go.drugbank.com/drugs/DB08958ApprovedWithdrawnA bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.
Mixtures: Isozid - H farblos - alkoholische Lösung zur Hautdesinfektion, Isozid - H gefärbt - alkoholische Lösung zur HautdesinfektionCategories: Heterocyclic Compounds, 1-RingProparacaine
go.drugbank.com/drugs/DB00807ApprovedVet approvedProparacaine is a topical anesthetic drug of the amino ester group. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt.
Mixtures: Mydriatic-4Products: PRIMAX EYE DROPS 5 mg/ml, BIOGLOKAINA® 0.5 % SOLUCION OFTALMICAOrlistat
go.drugbank.com/drugs/DB01083ApprovedInvestigationalIt was approved by the FDA for use in combination with a reduced-calorie diet in 1999. … [A229928] Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: ORALLI LW®, FINOBES ® 120 MG.Alteplase
go.drugbank.com/drugs/DB00009ApprovedInvestigationalAlteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent.[L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. … [A252330,L43125] Alteplase is a purified glycoprotein of 527 amino acids expressed in Chinese hamster ovary (CHO) cells.
Synonyms: t-PA, r-tPAProducts: Actilyse Cathflo 2 mg - Pulver zur Herstellung einer Injektionslösung, ACTILYSE 20 MG FLAKON, 1 ADETTryptophan 5-hydroxylase 1
go.drugbank.com/bio_entities/BE0000121TargetEnzymeHumansOxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis
Polypeptides: Tryptophan 5-hydroxylase 1Synonyms: Tryptophan 5-monooxygenase 1Cytosolic purine 5'-nucleotidase
go.drugbank.com/bio_entities/BE0000261TargetEnzymeHumansBroad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705).
Polypeptides: Cytosolic purine 5'-nucleotidaseSynonyms: High Km 5'-nucleotidase, Cytosolic 5'-nucleotidase II5'(3')-deoxyribonucleotidase, mitochondrial
go.drugbank.com/bio_entities/BE0001515TargetHumansDephosphorylates preferentially the 5'- and 2'(3')-phosphates of uracil and thymine (deoxy)ribonucleotide monophosphates (PubMed:10899995, PubMed:16004879).
Polypeptides: 5'(3')-deoxyribonucleotidase, mitochondrialSynonyms: Deoxy-5'-nucleotidase 2, dNT-25-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
go.drugbank.com/bio_entities/BE0001620TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Polypeptides: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseFunction: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity