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C-C chemokine receptor type 5
go.drugbank.com/bio_entities/BE0000911TargetHumansReceptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
Polypeptides: C-C chemokine receptor type 5Synonyms: HIV-1 fusion coreceptor, CCR-55-phosphohydroxy-L-lysine phospho-lyase
go.drugbank.com/bio_entities/BE0002164TargetHumansCatalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde
Polypeptides: 5-phosphohydroxy-L-lysine phospho-lyaseNeuronal acetylcholine receptor subunit alpha-5
go.drugbank.com/bio_entities/BE0003586TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-5Cytochrome b6-f complex subunit 5
go.drugbank.com/bio_entities/BE0003906TargetMastigocladus laminosusComponent of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assemb...
Polypeptides: Cytochrome b6-f complex subunit 5Tartrate-resistant acid phosphatase type 5
go.drugbank.com/bio_entities/BE0004487TargetHumansDephosphorylates a broad range of substrates, including adenosine 5'-diphosphate (ADP), adenosine 5'-triphosphate (ATP), as well as larger phosphoproteins such as osteopontin (SPP1), a highly phosphorylated
Polypeptides: Tartrate-resistant acid phosphatase type 5Synonyms: Type 5 acid phosphataseMAP kinase-activated protein kinase 5
go.drugbank.com/bio_entities/BE0009478TargetHumansTumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-...
Polypeptides: MAP kinase-activated protein kinase 5Synonyms: MK-5, MAPKAPK-5Solute carrier family 12 member 5
go.drugbank.com/bio_entities/BE0009674TransporterMouseMediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required f...
Polypeptides: Solute carrier family 12 member 53',5'-cyclic-AMP phosphodiesterase 4D
go.drugbank.com/bio_entities/BE0001287TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4DFunction: 3',5'-cyclic-AMP phosphodiesterase activitycGMP-dependent 3',5'-cyclic phosphodiesterase
go.drugbank.com/bio_entities/BE0002085TargetHumanscGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Ha...
Polypeptides: cGMP-dependent 3',5'-cyclic phosphodiesteraseFunction: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activitytRNA (cytosine(38)-C(5))-methyltransferase
go.drugbank.com/bio_entities/BE0002517TargetHumansSpecifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495)
Polypeptides: tRNA (cytosine(38)-C(5))-methyltransferaseSynonyms: DNA (cytosine-5)-methyltransferase-like protein 2