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Displaying results 5571 - 5580 of 10000 in total
  1. Drug

    Benznidazole

    go.drugbank.com/drugs/DB11989
    ApprovedInvestigational

    Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. … [L939] It is the first treatment made available in the United States for Chagas disease.

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesProducts: ABALEA ®100 MG
  2. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

    go.drugbank.com/bio_entities/BE0000089
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
  3. Target

    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

    go.drugbank.com/bio_entities/BE0000436
    TargetHumans

    Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has ...

    Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3AFunction: 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
  4. Target

    Type II inositol 1,4,5-trisphosphate 5-phosphatase

    go.drugbank.com/bio_entities/BE0004437
    TargetHumans

    Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events … Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P.

    Polypeptides: Type II inositol 1,4,5-trisphosphate 5-phosphataseSynonyms: Phosphoinositide 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase
  5. Target

    Insulin-like growth factor-binding protein 5

    go.drugbank.com/bio_entities/BE0009661
    CarrierHumans

    Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type spe...

    Polypeptides: Insulin-like growth factor-binding protein 5Synonyms: IBP-5, IGFBP-5
  6. Target

    Sodium channel protein type 5 subunit alpha

    go.drugbank.com/bio_entities/BE0000197
    TargetHumans

    Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). Navs, also called VGSCs (voltage-gated sod...

    Polypeptides: Sodium channel protein type 5 subunit alpha
  7. Target

    Tumor necrosis factor receptor superfamily member 5

    go.drugbank.com/bio_entities/BE0001196
    TargetHumans

    Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

    Polypeptides: Tumor necrosis factor receptor superfamily member 5
  8. Target

    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

    go.drugbank.com/bio_entities/BE0001223
    TargetHumans

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibitin...

    Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3BFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  9. Target

    NAD-dependent protein deacylase sirtuin-5, mitochondrial

    go.drugbank.com/bio_entities/BE0003362
    TargetHumans

    NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 an...

    Polypeptides: NAD-dependent protein deacylase sirtuin-5, mitochondrialSynonyms: SIR2-like protein 5, Regulatory protein SIR2 homolog 5
  10. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase

    go.drugbank.com/bio_entities/BE0004887
    EnzymeTargetHumans

    Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069) … Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: Steroid 5-alpha-reductase 1, S5AR 1