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Displaying results 551 - 560 of 10000 in total
  1. Drug

    Elenestinib

    go.drugbank.com/drugs/DB18489
    Investigational

    Elenestinib is a selective KIT inhibitor.

    Synonyms: (S)-2-(4-(4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol, 1H-Pyrazole-1-ethanol, 4-[4-[4-[5-[(1S)-1-amino-1-(4-fluorophenyl)ethyl]-2-pyrimidinyl]-1-piperazinyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl]-
  2. Indication

    Severe, active Crohn´s Disease

    go.drugbank.com/conditions/DBCOND0123591
    Drugs: Guselkumab · Risankizumab · Upadacitinib · Ustekinumab
    Synonyms: Severe, active Crohn´s Disease
  3. Target

    Glutathione S-transferase Mu 1

    go.drugbank.com/bio_entities/BE0000807
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). ...

    Polypeptides: Glutathione S-transferase Mu 1
  4. Target

    Glutathione S-transferase theta-1

    go.drugbank.com/bio_entities/BE0000818
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays...

    Polypeptides: Glutathione S-transferase theta-1
  5. Target

    G1/S-specific cyclin-D1

    go.drugbank.com/bio_entities/BE0001027
    TargetHumans

    Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition

    Polypeptides: G1/S-specific cyclin-D1
  6. Target

    Glutathione S-transferase 3, mitochondrial

    go.drugbank.com/bio_entities/BE0002279
    TargetEnzymeHumans

    Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:36370807, PubMed

    Polypeptides: Glutathione S-transferase 3, mitochondrial
  7. Target

    Glutathione S-transferase Mu 5

    go.drugbank.com/bio_entities/BE0002285
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

    Polypeptides: Glutathione S-transferase Mu 5
  8. Target

    Microsomal glutathione S-transferase 2

    go.drugbank.com/bio_entities/BE0002290
    TargetEnzymeHumans

    Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubM...

    Polypeptides: Microsomal glutathione S-transferase 2Synonyms: Microsomal glutathione S-transferase II
  9. Target

    Glutathione S-transferase omega-2

    go.drugbank.com/bio_entities/BE0002291
    TargetHumans

    Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monometh...

    Polypeptides: Glutathione S-transferase omega-2Synonyms: Glutathione S-transferase omega 2-2
  10. Target

    Vitamin K-dependent protein S

    go.drugbank.com/bio_entities/BE0000943
    TargetHumans

    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis

    Polypeptides: Vitamin K-dependent protein S